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Title: CT of multiple sclerosis: reassessment of delayed scanning with high doses of contrast material

A prospective study involving 87 patients was carried out to evaluate the necessity for a high dose of contrast material in addition to delayed computed tomographic (CT) scanning for optimal detection of the lesions of multiple sclerosis in the brain. In patients with either clinically definite multiple sclerosis or laboratory-supported definite multiple sclerosis, CT scans were obtained with a uniform protocol. Lesions consistent with multiple sclerosis were demonstrated on the second scan in 54 patients. In 36 of these 54 patients, the high-dose delayed scan added information. These results are quite similar to those of a previous study from this institution using different patients, in whom the second scan was obtained immediately after the bolus injection of contrast material containing 40 g of organically bound iodine. The lack of real difference in the results of the two studies indicate that the increased dose, not just the delay in scanning, is necessary for a proper study.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
5219134
Report Number(s):
CONF-860416-
Journal ID: CODEN: AAJRD; TRN: 85-023765
Resource Type:
Conference
Resource Relation:
Journal Name: AJR, Am. J. Roentgenol.; (United States); Journal Volume: 145:3; Conference: ARRS meeting, Washington, DC, USA, 14 Apr 1986
Research Org:
Univ. Hospital, London, Ontario
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; COMPUTERIZED TOMOGRAPHY; CONTRAST MEDIA; OPTIMIZATION; NERVOUS SYSTEM DISEASES; DIAGNOSIS; BLOOD-BRAIN BARRIER; PATIENTS; BODY; CENTRAL NERVOUS SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; NERVOUS SYSTEM; ORGANS; TOMOGRAPHY 550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)