Amount of mobilizable stem cells in perturbed hemopoiesis

Journal Article · Wed May 01 00:00:00 EDT 1985 · Int. J. Cell Cloning; (United States)

DOI:https://doi.org/10.1002/stem.5530030303· OSTI ID:5217704

Gidali, J; Feher, I

The level of mobilizable 9-day colony-forming units (CFU-s), which represents a constant fraction of the normal mouse bone marrow CFU-s pool, was assayed in BDF1 mice with perturbed hemopoiesis (i.e., during increased turnover of CFU-s or increased CFU-s traffic after irradiation). After low-level irradiation, regeneration of the mobilizable CFU-s fraction was significantly slower than that of bone marrow CFU-s. Depletion of the mobilizable CFU-s pool was observed if a permanently increased outflow of CFU-s from the bone marrow was induced by endotoxin injection. After 40% withdrawal of the blood volume, the mobilizable CFU-s pool expanded marginally. Assuming that the level of mobilizable CFU-s is a consequence of production and outflow from the bone marrow compartment, changes in the pool size of mobilizable CFU-s may be a sensitive indicator of balanced or unbalanced hemopoiesis.

• Research Organization: Frederic Joliot-Curie National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary
• OSTI ID: 5217704
• Journal Information: Int. J. Cell Cloning; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW CELLS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL REGENERATION
BLOOD
ENDOTOXINS
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
MICE
ANIMAL CELLS
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
MATERIALS
RADIATION EFFECTS
RADIATIONS
RECOVERY
RODENTS
SOMATIC CELLS
TOXIC MATERIALS
TOXINS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)