Chelation in metal intoxication XXI: chelation in lead intoxication during vitamin B complex deficiency

Journal Article · Mon Sep 01 00:00:00 EDT 1986 · Bull. Environ. Contam. Toxicol.; (United States)

OSTI ID:5217119

The vitamin B-complex deficiency increases the vulnerability to neuro- and systemic toxicity of Pb in young rats. Thus, the nutritional status of vitamins like that of protein or minerals seems to influence the etiology of Pb toxicity and may be expected to affect the response toward Pb chelators. 2,3 dimercaptosuccinic acid (DMSA) and N-(2-hydroxyethyl) ethylene-diamine triacetic acid (HEDTA) have been found to be effective antidotes to Pb intoxication. In the present study, these selective metal chelating agents were compared for their ability to reduce the body burden of Pb and restore the altered biochemical parameters in young developing Pb intoxicated rats maintained on normal or vitamin B-complex deficient diet. The investigation was aimed to suggest suitable prophylaxis of Pb poisoning prevalent among children who may also be suffering from vitamin deficiency in developing and poor countries.

• Research Organization: Industrial Toxicology Research Centre, Lucknow, India
• OSTI ID: 5217119
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 37:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHELATING AGENTS
BIOLOGICAL EFFECTS
LEAD COMPOUNDS
UPTAKE
VITAMIN B GROUP
NUTRITIONAL DEFICIENCY
BIOCHEMISTRY
HEDTA
RATS
AMINO ACIDS
ANIMALS
CARBOXYLIC ACIDS
CHEMISTRY
HYDROXY ACIDS
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
RODENTS
VERTEBRATES
VITAMINS
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)