Interactive effects of manganese and/or iron supplementation in adult women
Abstract
Evaluation of the practical significance of manganese-iron interactions has been hampered by the limited methodologies available to assess manganese status. Manganese status has not been monitored longitudinally in control studies with humans. Forty-eight women were recruited for a double blind 125-day supplementation study. After an initial 5-day baseline period, subjects were assigned to one of four treatments: placebo; 30 mg iron as ferrous fumarate daily; 15 mg manganese as an amino acid chelated manganese supplement daily or both the iron and manganese supplements daily. Dietary information, blood and 3-day urine samples were collected during the baseline period and after 20, 55, 85 and 120 days of consuming the supplements. Urinary manganese excretion ranged from 0.11 to 1.40 {mu}g/day. Serum manganese ranged from 0.16 to 1.92 {mu}g/l. Serum was also analyzed for iron, zinc, copper, ferritin and transferrin concentrations. Lymphocytes were isolated and manganese-dependent superoxide dismutase activity was determined as a new method to assess manganese status. Plasma cholesterol ranged from 126 to 229 mg/dl and HDL cholesterol ranged from 31 to 84 mg/dl. Plasma triglycerides were determined and LDL cholesterol was calculated by difference.
- Authors:
-
- Univ. of Wisconsin, Madison (United States)
- Publication Date:
- OSTI Identifier:
- 5213461
- Report Number(s):
- CONF-9104107-
Journal ID: ISSN 0892-6638; CODEN: FAJOE
- Resource Type:
- Conference
- Journal Name:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States)
- Additional Journal Information:
- Journal Volume: 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; Journal ID: ISSN 0892-6638
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; IRON; BIOLOGICAL EFFECTS; MANGANESE; SUPEROXIDE DISMUTASE; ENZYME ACTIVITY; BLOOD CHEMISTRY; CHOLESTEROL; LYMPHOCYTES; METABOLISM; WOMEN; ANIMAL CELLS; ANIMALS; BIOCHEMISTRY; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CHEMISTRY; CONNECTIVE TISSUE CELLS; ELEMENTS; ENZYMES; FEMALES; HYDROXY COMPOUNDS; LEUKOCYTES; MAMMALS; MAN; MATERIALS; METALS; ORGANIC COMPOUNDS; OXIDOREDUCTASES; PRIMATES; PROTEINS; SOMATIC CELLS; STEROIDS; STEROLS; TRANSITION ELEMENTS; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology
Citation Formats
Davis, C D, and Greger, J L. Interactive effects of manganese and/or iron supplementation in adult women. United States: N. p., 1991.
Web.
Davis, C D, & Greger, J L. Interactive effects of manganese and/or iron supplementation in adult women. United States.
Davis, C D, and Greger, J L. 1991.
"Interactive effects of manganese and/or iron supplementation in adult women". United States.
@article{osti_5213461,
title = {Interactive effects of manganese and/or iron supplementation in adult women},
author = {Davis, C D and Greger, J L},
abstractNote = {Evaluation of the practical significance of manganese-iron interactions has been hampered by the limited methodologies available to assess manganese status. Manganese status has not been monitored longitudinally in control studies with humans. Forty-eight women were recruited for a double blind 125-day supplementation study. After an initial 5-day baseline period, subjects were assigned to one of four treatments: placebo; 30 mg iron as ferrous fumarate daily; 15 mg manganese as an amino acid chelated manganese supplement daily or both the iron and manganese supplements daily. Dietary information, blood and 3-day urine samples were collected during the baseline period and after 20, 55, 85 and 120 days of consuming the supplements. Urinary manganese excretion ranged from 0.11 to 1.40 {mu}g/day. Serum manganese ranged from 0.16 to 1.92 {mu}g/l. Serum was also analyzed for iron, zinc, copper, ferritin and transferrin concentrations. Lymphocytes were isolated and manganese-dependent superoxide dismutase activity was determined as a new method to assess manganese status. Plasma cholesterol ranged from 126 to 229 mg/dl and HDL cholesterol ranged from 31 to 84 mg/dl. Plasma triglycerides were determined and LDL cholesterol was calculated by difference.},
doi = {},
url = {https://www.osti.gov/biblio/5213461},
journal = {FASEB Journal (Federation of American Societies for Experimental Biology); (United States)},
issn = {0892-6638},
number = ,
volume = 5:5,
place = {United States},
year = {Fri Mar 15 00:00:00 EST 1991},
month = {Fri Mar 15 00:00:00 EST 1991}
}