Interactions between dietary boron and thiamine affect lipid metabolism

Conference · Fri Mar 15 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5213289

Herbel, J L; Hunt, C D ^[1]

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1. Dept. of Agriculture, Grand Forks, ND (United States)

An experiment was designed to test the hypothesis that dietary boron impacts upon the function of various coenzymes involved in energy metabolism. In a 2 {times} 7 factorially-arranged experiment, weanling, vitamin D{sub 3}-deprived rats were fed a ground corn-casein-corn oil based diet supplemented with 0 or 2 mg boron/kg and 50% of the requirement for thiamine (TM), riboflavin (RF), pantothenic acid (PA) or pyridoxine (PX); 0% for folic acid (FA) or nicotinic acid (NA). All vitamins were supplemented in adequate amounts in the control diet. At 8 weeks of age, the TM dietary treatment was the one most affected by supplemental dietary boron (SDB). In rats that were fed 50% TM, SDB increased plasma concentrations of triglyceride (TG) and activity of alanine transaminase (ALT), and the liver to body weight (L/B) ratio. However, in the SDB animals, adequate amounts of TM decreased the means of those variables to near that observed in non-SDB rats fed 50% TM. The findings suggest that an interaction between dietary boron and TM affects lipid metabolism.

• OSTI ID: 5213289
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BORON
BIOLOGICAL EFFECTS
LIPIDS
METABOLISM
THIAMINE
BIOCHEMICAL REACTION KINETICS
AMINOTRANSFERASES
DIET
ENZYME ACTIVITY
RATS
TRIGLYCERIDES
AMINES
ANIMALS
AZINES
AZOLES
ELEMENTS
ENZYMES
ESTERS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
KINETICS
MAMMALS
NITROGEN TRANSFERASES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PROTEINS
PYRIMIDINES
REACTION KINETICS
RODENTS
SEMIMETALS
THIAZOLES
TRANSFERASES
VERTEBRATES
VITAMIN B GROUP
VITAMINS
560300* - Chemicals Metabolism & Toxicology