Simplified detection system for neuroreceptor studies in the human brain

Journal Article · Sat Feb 01 00:00:00 EST 1986 · J. Nucl. Med.; (United States)

OSTI ID:5207200

Bice, A N; Wagner, Jr, H N; Frost, J J; Natarajan, T K; Lee, M C; Wong, D F; Dannals, R F; Ravert, H T; Wilson, A A; Links, J M

A simple, inexpensive dual-detector system has been developed for measurement of positronemitting receptor-binding drugs in the human brain. This high efficiency coincidence counting system requires that only a few hundred microcuries of labeled drug be administered to the subject, thereby allowing for multiple studies without an excessive radiation dose. Measurement of the binding of (11C)carfentanil, a high affinity synthetic opiate, to opiate receptors in the presence and in the absence of a competitive opiate antagonist indicates the potential utility of this system for estimating different degrees of receptor occupation in the human brain.

• Research Organization: Johns Hopkins Medical Institutions, Baltimore, MD
• OSTI ID: 5207200
• Journal Information: J. Nucl. Med.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
NARCOTICS
RECEPTORS
BRAIN
LABELLED COMPOUNDS
SCINTILLATION COUNTING
BODY
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COUNTING TECHNIQUES
DRUGS
MEMBRANE PROTEINS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
550201* - Biochemistry- Tracer Techniques