Mutagenic activation of 2-aminofluorene by fluorescent light

Journal Article · Tue Jan 01 00:00:00 EST 1985 · Teratog., Carcinog., Mutagen.; (United States)

DOI:https://doi.org/10.1002/tcm.1770050108· OSTI ID:5186182

White, G L; Heflich, R H

To determine the effect of artificially produced light on the direct mutagenicity of 2-aminofluorene, that arylamine was irradiated with either sun, cool-white, black, blue, or yellow fluorescent light or held in the dark prior to assaying for mutagenicity using Salmonella typhimurium strain TA98. The order of effectiveness of these exposures in potentiating the mutagenicity of 2-aminofluorene was sun greater than black greater than cool-white greater than blue greater than yellow approximately equal to dark. By varying the radiant flux densities produced by the lamps and using optical filters, wavelengths of light up to approximately 450 nm were found to be effective in the mutagenic potentiation. Studies using radical scavengers and oxygen modifiers indicated that the light-induced mutagenicity was dependent on oxygen and that singlet oxygen may be an effective activator of 2-aminofluorene. The mutagenicity of fluorene was not increased by exposure to light, while only sunlight potentiated the mutagenicity of 2-acetylaminofluorene. This result suggested the importance of the primary amine in the mutagenic activation of 2-aminofluorene by light. These studies indicate that the effect of light on environmental contaminants must be considered in assessing their genotoxic potential.

• Research Organization: National Center for Toxicological Research, Jefferson, AR
• OSTI ID: 5186182
• Journal Information: Teratog., Carcinog., Mutagen.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
AMINES
CHEMICAL ACTIVATION
PHOTOCHEMISTRY
MUTAGENESIS
CONDENSED AROMATICS
FLUORESCENCE
HYDROCARBONS
MUTAGEN SCREENING
MUTAGENS
OXYGEN
RADIANT FLUX DENSITY
SALMONELLA TYPHIMURIUM
SOLAR RADIATION
AROMATICS
BACTERIA
CHEMISTRY
ELEMENTS
FLUX DENSITY
LUMINESCENCE
MICROORGANISMS
NONMETALS
ORGANIC COMPOUNDS
RADIATIONS
SALMONELLA
SCREENING
STELLAR RADIATION
400500* - Photochemistry