Genotoxic assessment of environmental tobacco smoke using bacterial bioassays
The paper demonstrates that integrated chemical and bacterial mutagenicity information can be used to identify environmental tobacco smoke genotoxicants, monitor human exposure, and make comparative assessments. Approximately one-third of the environmental tobacco-smoke constituents for which there is quantitative analytical-chemistry information also have associated genotoxicity information. For example, 11 of the quantitated compounds are animal carcinogens. Work presented in this paper demonstrates that both the nonparticle-bound semi-volatile and the particulate-bound organic material contain bacterial mutagens. These environmental tobacco-smoke organics give an equivalent of about 86,000 revertants per cigarette. In addition, this article summarizes efforts to estimate environmental tobacco smoke bacterial mutagenicity, to use bacterial tests for the monitoring of environmental tobacco smoke-impacted indoor environments, and to use bacterial assays for the direct monitoring of human exposure.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 5182206
- Report Number(s):
- PB-89-236327/XAB; EPA-600/J-89/014
- Resource Relation:
- Other Information: Pub. in Mutation Research, Vol. 222, 81-99(1989)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
54 ENVIRONMENTAL SCIENCES
MUTAGENESIS
BIOASSAY
MUTAGENS
INDOOR AIR POLLUTION
TOBACCO SMOKES
TOXIC MATERIALS
SALMONELLA TYPHIMURIUM
AEROSOLS
AIR POLLUTION
BACTERIA
COLLOIDS
DISPERSIONS
MATERIALS
MICROORGANISMS
POLLUTION
RESIDUES
SALMONELLA
SMOKES
SOLS
560300* - Chemicals Metabolism & Toxicology
540120 - Environment
Atmospheric- Chemicals Monitoring & Transport- (1990-)