Succinylcholine-induced hyperkalemia in the rat following radiation injury to muscle
During anesthetic preparation of a patient who had received routine radiation therapy for sarcoma of the leg, cardiac collapse occurred following succinylcholine (SCh) administration. Experiments were designed to test the hypothesis that radiation injury to muscle might cause increased sensitivity to SCh similar to that reported in patients with muscle trauma, severe burns, and lesions causing muscle denervation. Venous plasma potassium levels and arterial blood gas tensions were measured in rats after they were given SCh (3 mg/kg) at various times following /sup 60/Co irradiation of the hind legs. Nonirradiated rats responded to SCh with a slight but statistically significant increase in plasma K+. Rats subjected to high levels of radiation (10,000 to 20,000 R) and given SCh 4 to 7 days later responded in the same way as the control rats. Plasma K+ levels in rats exposed to a fractionated irradiated dosage (2500 R given twice with a 1-week interval) followed by SCh 1 week later were similar to those in the control group, but when SCh was given 2 weeks later (3 weeks after initial irradiation) there was a marked elevation of plasma K+, from 3.6 to 7.7 meq/L, a statistically significant increase.
- Research Organization:
- Univ. of Illinois, Abraham Lincoln School of Medicine, Chicago
- OSTI ID:
- 5175790
- Journal Information:
- Anesth. Analg. (Cleveland); (United States), Vol. 61:2
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HEART
BIOLOGICAL RADIATION EFFECTS
POTASSIUM
BIOCHEMICAL REACTION KINETICS
RADIOTHERAPY
SIDE EFFECTS
BLOOD PLASMA
CARDIOVASCULAR DISEASES
CHOLINE
COBALT 60
FRACTIONATED IRRADIATION
GAMMA RADIATION
LEGS
LOCAL IRRADIATION
PATIENTS
RADIATION DOSES
RATS
SARCOMAS
ALCOHOLS
ALKALI METALS
AMINES
AMMONIUM COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY AREAS
BODY FLUIDS
CARDIOVASCULAR SYSTEM
COBALT ISOTOPES
DISEASES
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LIMBS
LIPOTROPIC FACTORS
MAMMALS
MATERIALS
MEDICINE
METALS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
QUATERNARY COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
REACTION KINETICS
RODENTS
THERAPY
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550603* - Medicine- External Radiation in Therapy- (1980-)
560152 - Radiation Effects on Animals- Animals
560151 - Radiation Effects on Animals- Man
560114 - Radiation Effects on Biochemicals- In Animals- (-1987)