Influence of zinc deficiency on iron metabolism in rats

Conference · Fri Mar 15 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5174299

Liu, H; Loennerdal, B; Keen, C L ^[1]

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1. Univ. of California, Davis (United States)

It has been reported that one of the effects of dietary Zn deficiency is increased tissue Fe concentrations. One explanation for this is that Fe absorption is enhanced in Zn deficiency. An additional possibility is that Fe metabolism is altered in the deficient animal. To test this idea, the authors studied the effects of Zn deficiency on Fe metabolism in d 18 male rats fed diets ad libitum containing 0.3 ppm Zn (ZD) or 50 ppm Zn (C) for 2 wk. Following i.v. injection with a tracer dose of transferrin saturated with {sup 59}Fe, rats were killed at time intervals up to 120 min. Tissues were collected and analyzed for {sup 59}Fe radioactivity and mineral concentrations. Plasma, kidney, and liver Fe concentrations of ZD rats were higher than those of C rats while Zn concentrations were lower. At all time points, kidney and liver {sup 59}Fe retention on a per g basis was higher in the ZD rats than in the C rats. In contrast, there was no difference in the clearance of {sup 59}Fe from the plasma between the groups, implying that the higher tissue {sup 59}Fe retention in ZD rats was not due to a shortened biological half-life of Tf. The above data show that independent of Fe absorption, Zn deficiency can increase Fe retention, although the mechanism(s) underlying this effect remains to be determined.

• OSTI ID: 5174299
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
IRON
METABOLISM
ZINC
BIOLOGICAL EFFECTS
BIOLOGICAL HALF-LIFE
INTESTINAL ABSORPTION
IRON 59
NUTRITIONAL DEFICIENCY
RATS
TRACER TECHNIQUES
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METALS
NUCLEI
RADIOISOTOPES
RODENTS
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology