Selenium repletion protects neonatal rat lungs from hyperoxia

Conference · Fri Mar 15 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5173872

Kim, Hyeyoung; Wallig, M A; Picciano, M F ^[1]

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1. Univ. of Illinois, Urbana (United States) Pennsylvania State Univ., University Park (United States)

Previously the authors reported that selenium adequate rat pups were resistant to lung damage due to high O{sub 2} exposure. The present study was designed to assess whether Se-deficient pups repleted during postnatal period could also be protected from lung injury. Female SD rats were bred and fed a Se deficient diet during pregnancy. On day 2 postpartum, dams were divided into two groups and either continued on a Se{sup {minus}} diet or fed a Se supplemented diet. On day 5 postpartum, litters in each group were randomly assigned to either air or high O{sub 2} environments. Matched dams were rotated daily between litters in air and O{sub 2} for 4 days. Double-blinded, histopathologic scoring of lungs from 9 day old pup showed that Se repletion significantly reduced the incidence of septal attenuation and interstitial inflammation. Additionally lung volume of Se repleted pups were significantly enhanced. RNA/DNA ratio and glutathione concentration of lung were increased in response to hyperoxia, but unrelated to Se nutriture. These results show that postnatal Se repletion protects the developing lung from oxygen-induced injury.

• OSTI ID: 5173872
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LUNGS
SENSITIVITY
SELENIUM
BIOLOGICAL EFFECTS
ANOXIA
DIET
DNA
GLUTATHIONE
NEONATES
NUTRITIONAL DEFICIENCY
RATS
RNA
ANIMALS
BODY
DRUGS
ELEMENTS
MAMMALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RODENTS
SEMIMETALS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology