Decreased retinol in plasma of copper-deficient rats
- Dept. of Agriculture, Grand Forks, ND (United States)
There is increasing interest in oxidative effects in atherogenesis. Male, weanling rats of the Sprague-Dawley strain were matched by weight rats of the Sprague-Dawley strain were matched by weight into two groups of 10 and were fed a diet based on sucrose, egg white and corn oil deficient in copper and zinc and with vitamins A and E in excess of NRC recommendations. Retinol and {alpha}-tocopherol were measured in plasma by high performance liquid chromatography after hypercholesterolemia was detected. Retinol was decreased and {alpha}-tocopherol was increased by deficiency. Correction for cholestrolemia increased the effect on retinol and abolished the effect on retinol and abolished the effect on {alpha}-tocopherol. Epidemiologic association between mortality and vitamin A are not necessarily direct effects of low carotene intake; copper nutriture may be a hidden variable. The Western diet associated with high heart disease risk frequently is low in copper in comparison to putative requirements.
- OSTI ID:
- 5172548
- Report Number(s):
- CONF-9104107-; CODEN: FAJOE
- Journal Information:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARDIOVASCULAR DISEASES
PATHOGENESIS
COPPER
BIOLOGICAL EFFECTS
VITAMIN A
BIOSYNTHESIS
VITAMIN E
LIQUID COLUMN CHROMATOGRAPHY
METABOLISM
NUTRITIONAL DEFICIENCY
RATS
ANIMALS
CHROMATOGRAPHY
DISEASES
ELEMENTS
MAMMALS
METALS
RODENTS
SEPARATION PROCESSES
SYNTHESIS
TRANSITION ELEMENTS
VERTEBRATES
VITAMINS
560300* - Chemicals Metabolism & Toxicology