Pathogenesis of respiratory infections due to influenza virus: Implications for developing countries
- University of North Carolina, Chapel Hill (USA)
The influenza viruses have an important and distinctive place among respiratory viruses: they change antigenic character at irregular intervals, infect individuals of all ages, cause illnesses characterized by constitutional symptoms and tracheobronchitis, produce yearly epidemics associated frequently with excess morbidity and mortality, and predispose the host to bacterial superinfections. Much is known about influenza viruses, but their role in respiratory infections among children in developing countries is poorly understood, and the risk factors that lead to the excess morbidity and mortality have not been identified clearly. Among the many risk factors that may be important are alterations in host immunity, malnutrition, prior or coincident infections with other microorganisms, inhaled pollutants, and lack of access to medical care. There is a great need for research that can establish more precisely the role these and other unidentified factors play in the pathogenesis of influenza infections in children in the developing world. 37 references.
- OSTI ID:
- 5158839
- Journal Information:
- Reviews of Infectious Diseases; (United States), Vol. 13 Suppl 6; ISSN 0162-0886
- Country of Publication:
- United States
- Language:
- English
Similar Records
Topography of respiratory tract and gut microbiota in mice with influenza A virus infection
The Role of EGFR in Influenza Pathogenicity: Multiple Network-Based Approaches to Identify a Key Regulator of Non-lethal Infections
Related Subjects
INFLUENZA VIRUSES
INFECTIVITY
RESPIRATORY SYSTEM DISEASES
PATHOGENESIS
AIR POLLUTION
BIOLOGICAL EFFECTS
DEVELOPING COUNTRIES
IMMUNITY
INFLUENZA
MAN
RISK ASSESSMENT
ANIMALS
DISEASES
INFECTIOUS DISEASES
MAMMALS
MICROORGANISMS
PARASITES
POLLUTION
PRIMATES
VERTEBRATES
VIRAL DISEASES
VIRUSES
560300* - Chemicals Metabolism & Toxicology