Identification of chemicals carcinogenic to man

Journal Article · Sun Jan 01 00:00:00 EST 1984 · Toxicol. Pathol.; (United States)

DOI:https://doi.org/10.1177/019262338401200415· OSTI ID:5147252

Wilbourn, J D; Haroun, L; Vainio, H; Montesano, R

Although both the epidemiologic and experimental studies have led to the identification of chemical carcinogens, the limitations in epidemiologic approaches and the need for primary prevention of cancer require a greater reliance on experimental studies. Long-term carcinogenicity studies in experimental animals have been instrumental in identifying chemicals with carcinogenic activity, and, in some cases, the experimental evidence has preceded the epidemiologic evidence (for 4-aminobiphenyl, aflatoxin B1, diethylstilbestrol, melphalan, mustard gas, and vinyl chloride). A better understanding of the multistage process of carcinogenesis and the findings from various short-term tests available more recently may provide a more solid basis for extrapolating experimental findings to man.

• Research Organization: International Agency for Research on Cancer, Lyon, France
• OSTI ID: 5147252
• Journal Information: Toxicol. Pathol.; (United States), Vol. 4
• Country of Publication: United States
• Language: English

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