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Title: Identification of chemicals carcinogenic to man

Abstract

Although both the epidemiologic and experimental studies have led to the identification of chemical carcinogens, the limitations in epidemiologic approaches and the need for primary prevention of cancer require a greater reliance on experimental studies. Long-term carcinogenicity studies in experimental animals have been instrumental in identifying chemicals with carcinogenic activity, and, in some cases, the experimental evidence has preceded the epidemiologic evidence (for 4-aminobiphenyl, aflatoxin B1, diethylstilbestrol, melphalan, mustard gas, and vinyl chloride). A better understanding of the multistage process of carcinogenesis and the findings from various short-term tests available more recently may provide a more solid basis for extrapolating experimental findings to man.

Authors:
; ; ;
Publication Date:
Research Org.:
International Agency for Research on Cancer, Lyon, France
OSTI Identifier:
5147252
Resource Type:
Journal Article
Journal Name:
Toxicol. Pathol.; (United States)
Additional Journal Information:
Journal Volume: 4
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARCINOGEN SCREENING; EXPERIMENT PLANNING; CARCINOGENESIS; RISK ASSESSMENT; CARCINOGENS; ENVIRONMENTAL EXPOSURE; EPIDEMIOLOGY; MAN; ANIMALS; MAMMALS; PATHOGENESIS; PLANNING; PRIMATES; SCREENING; VERTEBRATES; 560306* - Chemicals Metabolism & Toxicology- Man- (-1987)

Citation Formats

Wilbourn, J D, Haroun, L, Vainio, H, and Montesano, R. Identification of chemicals carcinogenic to man. United States: N. p., 1984. Web. doi:10.1177/019262338401200415.
Wilbourn, J D, Haroun, L, Vainio, H, & Montesano, R. Identification of chemicals carcinogenic to man. United States. https://doi.org/10.1177/019262338401200415
Wilbourn, J D, Haroun, L, Vainio, H, and Montesano, R. 1984. "Identification of chemicals carcinogenic to man". United States. https://doi.org/10.1177/019262338401200415.
@article{osti_5147252,
title = {Identification of chemicals carcinogenic to man},
author = {Wilbourn, J D and Haroun, L and Vainio, H and Montesano, R},
abstractNote = {Although both the epidemiologic and experimental studies have led to the identification of chemical carcinogens, the limitations in epidemiologic approaches and the need for primary prevention of cancer require a greater reliance on experimental studies. Long-term carcinogenicity studies in experimental animals have been instrumental in identifying chemicals with carcinogenic activity, and, in some cases, the experimental evidence has preceded the epidemiologic evidence (for 4-aminobiphenyl, aflatoxin B1, diethylstilbestrol, melphalan, mustard gas, and vinyl chloride). A better understanding of the multistage process of carcinogenesis and the findings from various short-term tests available more recently may provide a more solid basis for extrapolating experimental findings to man.},
doi = {10.1177/019262338401200415},
url = {https://www.osti.gov/biblio/5147252}, journal = {Toxicol. Pathol.; (United States)},
number = ,
volume = 4,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1984},
month = {Sun Jan 01 00:00:00 EST 1984}
}