Zinc deficiency (ZD) without starvation affects thyroid hormone metabolism of rats

Conference · Fri Mar 15 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5146581

Lukaski, H C; Smith, S M; Hall, C B; Bucher, D R ^[1]

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1. Dept. of Agriculture, Grand Forks, ND (United States)

Young rats fed diets severely deficient in Zn exhibit impaired growth and endocrine function. These hormone effects may be confounded by cyclical feeding and starvation. To examine the effects of zinc deficiency (ZD) with and without starvation, 40 male weanling Sprague-Dawley rats were fed a semipurified diet containing all essential nutrients and 30 ppm Zn until they weighed 150 g, then were matched by weight into four groups and were fed one of the following diets for 28d: ad lib control Zn diet, marginal ZD diet, severe ZD diet, and C diet pair-fed (PF) in amounts consumed by matched ZD1 rat. Food intake was depressed in ZD1; body weights were reduced in ZD1 and PF. There was no difference in either food intake or weight gain between C and ZD6. ZD reduced liver and femur Zn concentrations. Plasma thyroxine (T{sub 4}) concentration was greater in ZD6 then ZD1 or PF, but less than C; triodothyronine concentration was less in PF than C, but similar to ZD1 and ZD6. Hepatic T{sub 4}-5{prime}-deiodinase activity was greater in ZD6 than ZD1 or PF, but less than C. These findings indicate that altered thyroid hormone metabolism of severe ZD is related to Zn intake and starvation, whereas ZD uncomplicated by starvation affects peripheral deiodination of T{sub 4}, and suggests altered rates of thyroid hormone synthesis or degradation.

• OSTI ID: 5146581
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
THYROID HORMONES
METABOLISM
ZINC
BIOLOGICAL EFFECTS
DIET
FASTING
NUTRITIONAL DEFICIENCY
RATS
ANIMALS
ELEMENTS
HORMONES
MAMMALS
METALS
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PROTEINS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology