Controlled exposure of volunteers with chronic obstructive pulmonary disease to sulfur dioxide

Linn, W S; Fischer, D A; Shamoo, D A; Spier, C E; Valencia, L M; Anzar, U T; Hackney, J D

doi:10.1016/0013-9351(85)90126-4

Title: Controlled exposure of volunteers with chronic obstructive pulmonary disease to sulfur dioxide

Full Record
Other Related Research

Abstract

Twenty-four volunteers with chronic obstructive pulmonary disease (COPD) were exposed to sulfur dioxide (SO/sub 2/) at 0, 0.4, and 0.8 ppm in an environmental control chamber. Exposures lasted 1 hr and included two 15-min exercise periods (mean exercise ventilation rate 18 liter/min). Pulmonary mechanical function was evaluated before exposures, after initial exercise, and at the end of exposure. Blood oxygenation was measured by ear oximetry before exposure and during the second exercise period. Symptoms were recorded throughout exposure periods and for 1 week afterward. No statistically significant changes in physiology or symptoms could be attributed to SO/sub 2/ exposure. Older adults with COPD seem less reactive to a given concentration of SO/sub 2/ than heavily exercising young adult asthmatics. This may be due to lower ventilation rates (i.e., lower SO/sub 2/ dose rates) and/or to lower airway reactivity in the COPD group.

Authors:: Linn, W S; Fischer, D A; Shamoo, D A; Spier, C E; Valencia, L M; Anzar, U T; Hackney, J D

Publication Date:: Thu Aug 01 00:00:00 EDT 1985

Research Org.:: Univ. of Southern California, Downey

OSTI Identifier:: 5145313

Resource Type:: Journal Article

Journal Name:: Environ. Res.; (United States)

Additional Journal Information:: Journal Volume: 37:2

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LUNGS; BIOLOGICAL FUNCTIONS; SULFUR DIOXIDE; BIOLOGICAL EFFECTS; EXERCISE; EXPERIMENTAL DATA; EXPOSURE CHAMBERS; PATIENTS; PHYSIOLOGY; RESPIRATORY SYSTEM DISEASES; SYMPTOMS; BODY; CHALCOGENIDES; DATA; DISEASES; FUNCTIONS; INFORMATION; NUMERICAL DATA; ORGANS; OXIDES; OXYGEN COMPOUNDS; RESPIRATORY SYSTEM; SULFUR COMPOUNDS; SULFUR OXIDES; 560306* - Chemicals Metabolism & Toxicology- Man- (-1987)

Citation Formats


                    Linn, W S, Fischer, D A, Shamoo, D A, Spier, C E, Valencia, L M, Anzar, U T, and Hackney, J D. Controlled exposure of volunteers with chronic obstructive pulmonary disease to sulfur dioxide.  United States: N. p., 1985. 
        Web.  doi:10.1016/0013-9351(85)90126-4.

Copy to clipboard


                    Linn, W S, Fischer, D A, Shamoo, D A, Spier, C E, Valencia, L M, Anzar, U T, & Hackney, J D. Controlled exposure of volunteers with chronic obstructive pulmonary disease to sulfur dioxide.  United States.  https://doi.org/10.1016/0013-9351(85)90126-4

Copy to clipboard


                    Linn, W S, Fischer, D A, Shamoo, D A, Spier, C E, Valencia, L M, Anzar, U T, and Hackney, J D. 1985.  
        "Controlled exposure of volunteers with chronic obstructive pulmonary disease to sulfur dioxide".  United States.  https://doi.org/10.1016/0013-9351(85)90126-4.

Copy to clipboard


                    
@article{osti_5145313,

  title        = {Controlled exposure of volunteers with chronic obstructive pulmonary disease to sulfur dioxide},

  author       = {Linn, W S and Fischer, D A and Shamoo, D A and Spier, C E and Valencia, L M and Anzar, U T and Hackney, J D},

  abstractNote = {Twenty-four volunteers with chronic obstructive pulmonary disease (COPD) were exposed to sulfur dioxide (SO/sub 2/) at 0, 0.4, and 0.8 ppm in an environmental control chamber. Exposures lasted 1 hr and included two 15-min exercise periods (mean exercise ventilation rate 18 liter/min). Pulmonary mechanical function was evaluated before exposures, after initial exercise, and at the end of exposure. Blood oxygenation was measured by ear oximetry before exposure and during the second exercise period. Symptoms were recorded throughout exposure periods and for 1 week afterward. No statistically significant changes in physiology or symptoms could be attributed to SO/sub 2/ exposure. Older adults with COPD seem less reactive to a given concentration of SO/sub 2/ than heavily exercising young adult asthmatics. This may be due to lower ventilation rates (i.e., lower SO/sub 2/ dose rates) and/or to lower airway reactivity in the COPD group.},

  doi          = {10.1016/0013-9351(85)90126-4},

  url          = {https://www.osti.gov/biblio/5145313},
  journal      = {Environ. Res.; (United States)},
number       = ,

  volume       = 37:2,

  place        = {United States},

  year         = {Thu Aug 01 00:00:00 EDT 1985},

  month        = {Thu Aug 01 00:00:00 EDT 1985}

}

Copy to clipboard

Journal Article:

https://doi.org/10.1016/0013-9351(85)90126-4

Other availability

Find in Google Scholar

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar records in OSTI.GOV collections:

Controlled exposure of volunteers with chronic obstructive pulmonary disease to nitrogen dioxide

Journal Article Linn, W; Shamoo, D; Spier, C; ...

Twenty-two volunteers with chronic obstructive pulmonary disease were exposed to nitrogen dioxide at 0.0, 0.5, 1.0, and 2.0 ppm in a controlled environment chamber. Exposure lasted 1 hr and included two 15-min exercise periods, during which the mean ventilation rate was roughly 16 L/min. Pulmonary mechanical function was evaluated pre-exposure, after initial exercise, and at the end of exposure. Blood oxygenation was measured by ear oximetry pre-exposure and during the second exposure period. Symptoms were recorded during exposures and for 1-wk periods afterward. No statistically significant changes in symptom reporting could be attributed to nitrogen dioxide exposure at any concentration,more »« less
https://doi.org/10.1080/00039896.1985.10545939
Acute effects of 0. 2 ppm ozone in patients with chronic obstructive pulmonary disease

Journal Article Solic, J; Hazucha, M; Bromberg, P - Am. Rev. Respir. Dis.; (United States)

Epidemiologic data suggest that patients with chronic obstructive pulmonary disease (COPD) might be more sensitive than normal persons to the respiratory effects of oxidant pollutant exposure. Our study was designed to determine the response of patients with COPD to ozone. Thirteen white men with nonreversible airways obstruction (mean FEV1/FVC, 58%), of whom 8 were current smokers, were randomly exposed for 2 h to air and to 0.2 ppm ozone on 2 consecutive days using a single-blind crossover design. During either exposure, subjects exercised for 7.5 min every 30 min. Measures of respiratory mechanics obtained pre-exposure and postexposure were not significantlymore »« less
Respiratory responses of exercising asthmatic volunteers exposed to sulfuric acid aerosol

Journal Article Linn, W; Avol, E; Shamoo, D; ... - J. Air Pollut. Control Assoc.; (United States)

Young asthmatic adult volunteers (N = 27) were exposed in an environmental chamber to sulfuric acid aerosol at concentrations near 0, 122, 242, and 410 ..mu..g/m/sup 3/, in purified background air at 22/sup 0/C and 50 percent relative humidity. The polydisperse aerosol had a mass median aerodynamic diameter near 0.6 ..mu..m. Exposures occurred in random order at one-week intervals. Each lasted 1 h, during which subjects exercised (mean ventilation 42 L/min) and rested during alternate 10-min periods. Specific airway resistance and forced expiratory function were measured pre-exposure, after the initial exercise, and at end-exposure. Bronchial reactivity was determined by challengemore »« less
https://doi.org/10.1080/00022470.1986.10466181
Short-term respiratory effects of sulfuric acid in fog: a laboratory study of healthy and asthmatic volunteers

Journal Article Avol, E; Linn, W; Wightman, L; ... - J. Air Pollut. Control Assoc.; (United States)

To explore short-term respiratory health risks from acid-polluted fog, 22 normal and 22 asthmatic adult volunteers were exposed in an environmental control chamber to light fogs containing nominally 0, 500, 1000, and 2000 ..mu..g/m/sup 3/ of sulfuric acid. Fog was produced by atomizing dilute acid solution into purified air humidified to near 100% by stem injection. Exposures were administered in random order at 1-week intervals, lasted 1 h, and included three 10-min periods of moderately heavy exercise. Responses were measured in terms of forced expiratory function, airway resistance, irritant symptoms, and bronchial reactivity to methacholine aerosol. Sulfuric acid per semore »« less
https://doi.org/10.1080/08940630.1988.10466375
Controlled exposures of volunteers to respirable carbon and sulfuric acid aerosols

Journal Article Anderson, K; Avol, E; Edwards, S; ... - Journal of the Air and Waste Management Association; (United States)

Respirable carbon or fly ash particles are suspected to increase the respiratory toxicity of coexisting acidic air pollutants, by concentrating acid on their surfaces and so delivering it efficiently to the lower respiratory tract. To investigate this issue, the authors exposed 15 healthy and 15 asthmatic volunteers in a controlled-environment chamber to four test atmospheres: (1) clean air; (2) 0.5-{mu}m H{sub 2}SO{sub 4} aerosol at {approx}100 {mu}g/m{sup 3}, generated from water solution; (3) 0.5-{mu}m carbon aerosol at {approx}250 {mu}g/m{sup 3}, generated from highly pure carbon black with specific surface area comparable to ambient pollution particles; and (4) carbon as inmore »« less
https://doi.org/10.1080/10473289.1992.10467028

Similar Records