Effect of SO/sub 2/ on the clearance of Listeria monocytogenes from the lungs of emphysematous hamsters

Journal Article · Wed Oct 01 00:00:00 EDT 1986 · Environ. Res.; (United States)

OSTI ID:5144048

Trimpe, K L; Weiss, H; Zwilling, B S

The effect of sulfur dioxide on the clearance of Listeria monocytogenes from normal and emphysematous hamsters was assessed by measuring the number of colony forming units recovered from whole lung homogenates. Continuous exposure to SO/sub 2/ after intratracheal instillation of Listeria significantly altered the clearance of viable bacteria from the lungs of emphysematous but not normal hamsters. Pre-exposure of hamsters to SO/sub 2/ for 2 weeks prior to respiratory infection had similar effects. The emphysematous hamsters exposed to SO/sub 2/ had a lower average number of Listeria in the lungs after the first week of infection than control groups. This effect appears to result from the combined influence of the SO/sub 2/, the Listeria infection, and the emphysematous condition within the lungs.

• Research Organization: Ohio State Univ., Columbus
• OSTI ID: 5144048
• Journal Information: Environ. Res.; (United States), Vol. 41:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
LUNG CLEARANCE
SULFUR DIOXIDE
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
CFU
EMPHYSEMA
EXPERIMENTAL DATA
HAMSTERS
INTRATRACHEAL ADMINISTRATION
RESPIRATORY SYSTEM
ANIMALS
CHALCOGENIDES
CLEARANCE
DATA
DISEASES
EXCRETION
INFORMATION
MAMMALS
MICROORGANISMS
NUMERICAL DATA
OXIDES
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM DISEASES
RODENTS
SULFUR COMPOUNDS
SULFUR OXIDES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)