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Title: Splenic uptake of both technetium-99m diphosphonate and technetium-99m sulfur colloid in sickle cell beta degrees thalassemia

Abstract

A 19-year-old black woman with sickle cell beta degrees thalassemia had experienced more than 100 hospital admissions for sickle cell crisis and aseptic necrosis of both femoral heads. Her spleen was enlarged threefold and accumulated both radiocolloid and bone-seeking agent on two occasions, demonstrating an exception to the rule in sickle cell anemia that spleens that take up bone-seeking agents demonstrate functional asplenia. In the context of fever, left upper quadrant pain, and splenomegaly, the pattern of calcification in the patient's spleen as revealed in ultrasound and CT studies suggested possible abscess and led to unnecessary splenectomy. The nuclear medicine studies did not support this diagnosis. Nuclear medicine physicians should not be misled by splenic findings of sickle cell thalassemia (and possibly of other heterozygous sickle cell disorders) that differ from those of the more familiar homozygous sickle cell anemia.

Authors:
;  [1]
  1. Methodist Hospital of Indiana, IN (USA)
Publication Date:
OSTI Identifier:
5128822
Resource Type:
Journal Article
Journal Name:
Clinical Nuclear Medicine; (USA)
Additional Journal Information:
Journal Volume: 14:8; Journal ID: ISSN 0363-9762
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; SICKLE CELL ANEMIA; DIAGNOSIS; SPLEEN; RADIONUCLIDE KINETICS; TECHNETIUM 99; UPTAKE; COLLOIDS; COMPUTERIZED TOMOGRAPHY; ULTRASONOGRAPHY; ANEMIAS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DIAGNOSTIC TECHNIQUES; DISEASES; DISPERSIONS; HEMIC DISEASES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; SYMPTOMS; TECHNETIUM ISOTOPES; TOMOGRAPHY; YEARS LIVING RADIOISOTOPES; 560161* - Radionuclide Effects, Kinetics, & Toxicology- Man; 550601 - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Heck, L L, and Brittin, G M. Splenic uptake of both technetium-99m diphosphonate and technetium-99m sulfur colloid in sickle cell beta degrees thalassemia. United States: N. p., 1989. Web. doi:10.1097/00003072-198908000-00001.
Heck, L L, & Brittin, G M. Splenic uptake of both technetium-99m diphosphonate and technetium-99m sulfur colloid in sickle cell beta degrees thalassemia. United States. https://doi.org/10.1097/00003072-198908000-00001
Heck, L L, and Brittin, G M. 1989. "Splenic uptake of both technetium-99m diphosphonate and technetium-99m sulfur colloid in sickle cell beta degrees thalassemia". United States. https://doi.org/10.1097/00003072-198908000-00001.
@article{osti_5128822,
title = {Splenic uptake of both technetium-99m diphosphonate and technetium-99m sulfur colloid in sickle cell beta degrees thalassemia},
author = {Heck, L L and Brittin, G M},
abstractNote = {A 19-year-old black woman with sickle cell beta degrees thalassemia had experienced more than 100 hospital admissions for sickle cell crisis and aseptic necrosis of both femoral heads. Her spleen was enlarged threefold and accumulated both radiocolloid and bone-seeking agent on two occasions, demonstrating an exception to the rule in sickle cell anemia that spleens that take up bone-seeking agents demonstrate functional asplenia. In the context of fever, left upper quadrant pain, and splenomegaly, the pattern of calcification in the patient's spleen as revealed in ultrasound and CT studies suggested possible abscess and led to unnecessary splenectomy. The nuclear medicine studies did not support this diagnosis. Nuclear medicine physicians should not be misled by splenic findings of sickle cell thalassemia (and possibly of other heterozygous sickle cell disorders) that differ from those of the more familiar homozygous sickle cell anemia.},
doi = {10.1097/00003072-198908000-00001},
url = {https://www.osti.gov/biblio/5128822}, journal = {Clinical Nuclear Medicine; (USA)},
issn = {0363-9762},
number = ,
volume = 14:8,
place = {United States},
year = {Tue Aug 01 00:00:00 EDT 1989},
month = {Tue Aug 01 00:00:00 EDT 1989}
}