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Title: Improved exercise myocardial perfusion during lidoflazine therapy

Lidoflazine is a synthetic drug with calcium-channel blocking effects. In a study of 6 patients with severe classic angina pectoris, single-blind administration of lidoflazine was associated with improved myocardial perfusion during exercise as determined by thallium-201 stress scintigraphy. These studies demonstrate that lidoflazine therapy is associated with relief of angina, an increased physical work capacity, and improved regional myocardial perfusion during exercise.
Authors:
; ;
Publication Date:
OSTI Identifier:
5128509
Resource Type:
Journal Article
Resource Relation:
Journal Name: Angiology; (United States); Journal Volume: 34:11
Research Org:
Cardiovascular Section, Veterans Administration Medical, Torrence, California
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; MYOCARDIUM; SCINTISCANNING; PIPERAZINES; HEALTH HAZARDS; BIOLOGICAL STRESS; DYNAMIC FUNCTION STUDIES; EXERCISE; MEMBRANE TRANSPORT; PATIENTS; PERFUSED TISSUES; THALLIUM 201; ANIMAL TISSUES; AZINES; BETA DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; ELECTRON CAPTURE RADIOISOTOPES; HAZARDS; HEART; HEAVY NUCLEI; HETEROCYCLIC COMPOUNDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRAZINES; RADIOISOTOPE SCANNING; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; THALLIUM ISOTOPES; TISSUES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics