Comparison of Herpes simplex virus plaque development after viral treatment with anti-DNA or antilipid agents

Journal Article · Sun Jun 01 00:00:00 EDT 1980 · Biophys. J.; (United States)

DOI:https://doi.org/10.1016/S0006-3495(80)85111-3· OSTI ID:5126268

Coohill, T P; Babich, M; Taylor, W D; Snipes, W

The plaque development of Herpes simplex virus type 1 (HSV) is slower for viruses treated with two anti-DNA agents: ultraviolet radiation (uv) or n-acetoxy-2-acetyl-aminofluorene. For HSV treated with three antimembrane agents - butylated hydroxytoluene, acridine plus near uv radiation, or ether - the plaque development time is the same as for untreated viruses. These differences hold even for viruses that survived treatment that lowered viability below the 1% level. Gamma ray inactivation of HSV produces no change in plaque development even though this agent is believed to preferentially affect viral DNA.

• Research Organization: Western Kentucky Univ., Bowling Green
• OSTI ID: 5126268
• Journal Information: Biophys. J.; (United States), Vol. 30:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
HERPES SIMPLEX
RADIOSENSITIVITY
PLAQUE FORMATION
BIOLOGICAL RADIATION EFFECTS
ACRIDINES
DNA
FLUORENE
GAMMA RADIATION
HYDROXY COMPOUNDS
MEMBRANES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
TIME DEPENDENCE
TOLUENE
ULTRAVIOLET RADIATION
AROMATICS
AZINES
BIOLOGICAL EFFECTS
CONDENSED AROMATICS
DISEASES
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
INFECTIOUS DISEASES
IONIZING RADIATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIDINES
RADIATION EFFECTS
RADIATIONS
SKIN DISEASES
560132* - Radiation Effects on Microorganisms- Food Preservation- (-1987)
550700 - Microbiology
560302 - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)