Postnatal development of bile secretory physiology in the dog
To determine whether bile formation in the dog is an immature process at birth, several determinants of bile secretion were studied in anesthetized, bile duct-cannulated puppies of 0-42 days of age and adult dogs. Basal canalicular bile flow rate, estimated by /sup 14/C-erythritol biliary clearance, averaged 0.182 microliter/min/g liver in 0-3 day-old puppies and increased to 0.324 and 0.461 microliter/min/g in puppies 7-21 and 28-42 days of age, respectively. Calculated ductular bile water reabsorption (/sup 14/C-erythritol biliary clearance-bile flow) was virtually absent in 0-3 day-old puppies, and averaged 0.017 and 0.092 microliter/min/g in puppies of 7-21 and 28-42 days of age, respectively. In adult dogs, ductular bile water reabsorption was 0.132 microliter/min/g. These functional deficiencies of the newborn dog were associated with an increased biliary permeability to /sup 3/H-inulin which could not be accounted for solely by an increased solute diffusion due to the lower rate of canalicular bile flow. Administration of taurocholate up to 2000 nmol/min/kg produced in all animals a similar increase in canalicular bile flow and bile acid excretion, and was not associated with changes in ductular bile water reabsorption rate. These findings are interpreted to indicate that, in the dog, bile secretory function is immature at birth and develops during postnatal life.
- Research Organization:
- Polly Annenberg Levee Hematology Center, New York, NY
- OSTI ID:
- 5125375
- Journal Information:
- J. Pediatr. Gastroenterol. Nutr.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
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BILE
SECRETION
BILIARY TRACT
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TRACER TECHNIQUES
TRITIUM COMPOUNDS
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AGE DEPENDENCE
DOGS
ERYTHRITOL
INULIN
LIVER
PERMEABILITY
AGE GROUPS
ALCOHOLS
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOHYDRATES
DIGESTIVE SYSTEM
GLANDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
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ORGANS
POLYSACCHARIDES
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VERTEBRATES
551001* - Physiological Systems- Tracer Techniques