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Title: Abnormal lymphocyte response to ultraviolet radiation in multiple skin cancer

Abstract

The lymphocyte response to ultraviolet radiation (254 nm) was investigated by two different methods in 29 unselected patients with multiple epidermal cancer. The ultraviolet-induced DNA synthesis was determined as the increase in incorporation of (/sup 3/H)thymidine in irradiated cells compared with non-irradiated cells after incubation for 2 h. The ultraviolet tolerance was measured as the ultraviolet dose necessary for 50% reduction in phytohemagglutinin-stimulated lymphocyte proliferation. Patients with both squamous cell differentiated tumours and basal cell carcinomas had very high ultraviolet-induced DNA synthesis values. The ultraviolet tolerance in patient lymphocytes was considerably lower than in control lymphocytes with the lowest values occurring in patients with clinical sun intolerance. These investigations may be of predictive value in skin carcinogenesis.

Authors:
; ; ; ; ; ;  [1]
  1. Finseninstitutet, Copenhagen (Denmark)
Publication Date:
OSTI Identifier:
5124693
Resource Type:
Journal Article
Journal Name:
Carcinogenesis (N.Y.); (United States)
Additional Journal Information:
Journal Volume: 6:6
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LYMPHOCYTES; BIOLOGICAL RADIATION EFFECTS; CELL PROLIFERATION; SKIN; NEOPLASMS; DNA REPLICATION; NEAR ULTRAVIOLET RADIATION; PATIENTS; THYMINE; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ANIMAL CELLS; AZINES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; LEUKOCYTES; MATERIALS; NUCLEIC ACID REPLICATION; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIMIDINES; RADIATION EFFECTS; RADIATIONS; SOMATIC CELLS; ULTRAVIOLET RADIATION; URACILS; 560121* - Radiation Effects on Cells- External Source- (-1987)

Citation Formats

Munch-Petersen, B, Frentz, G, Squire, B, Wallevik, K, Horn, C C, Reymann, F, and Faber, M. Abnormal lymphocyte response to ultraviolet radiation in multiple skin cancer. United States: N. p., 1985. Web. doi:10.1093/carcin/6.6.843.
Munch-Petersen, B, Frentz, G, Squire, B, Wallevik, K, Horn, C C, Reymann, F, & Faber, M. Abnormal lymphocyte response to ultraviolet radiation in multiple skin cancer. United States. https://doi.org/10.1093/carcin/6.6.843
Munch-Petersen, B, Frentz, G, Squire, B, Wallevik, K, Horn, C C, Reymann, F, and Faber, M. 1985. "Abnormal lymphocyte response to ultraviolet radiation in multiple skin cancer". United States. https://doi.org/10.1093/carcin/6.6.843.
@article{osti_5124693,
title = {Abnormal lymphocyte response to ultraviolet radiation in multiple skin cancer},
author = {Munch-Petersen, B and Frentz, G and Squire, B and Wallevik, K and Horn, C C and Reymann, F and Faber, M},
abstractNote = {The lymphocyte response to ultraviolet radiation (254 nm) was investigated by two different methods in 29 unselected patients with multiple epidermal cancer. The ultraviolet-induced DNA synthesis was determined as the increase in incorporation of (/sup 3/H)thymidine in irradiated cells compared with non-irradiated cells after incubation for 2 h. The ultraviolet tolerance was measured as the ultraviolet dose necessary for 50% reduction in phytohemagglutinin-stimulated lymphocyte proliferation. Patients with both squamous cell differentiated tumours and basal cell carcinomas had very high ultraviolet-induced DNA synthesis values. The ultraviolet tolerance in patient lymphocytes was considerably lower than in control lymphocytes with the lowest values occurring in patients with clinical sun intolerance. These investigations may be of predictive value in skin carcinogenesis.},
doi = {10.1093/carcin/6.6.843},
url = {https://www.osti.gov/biblio/5124693}, journal = {Carcinogenesis (N.Y.); (United States)},
number = ,
volume = 6:6,
place = {United States},
year = {Sat Jun 01 00:00:00 EDT 1985},
month = {Sat Jun 01 00:00:00 EDT 1985}
}