Combined effects of streptozotocin-diabetes and ionizing radiation on nephropathy in the rat
The individual effects of radiation and diabetes on nephropathy in the rat are well-documented; however, the combined effects of these factors on nephropathy have not been adequately studied. The combined effect of radiation and diabetes on nephropathy is a significant problem in view of human populations at risk; diabetic radiation workers and diabetic radiotherapy patients. Streptozotocin-diabetic and control rats were irradiated using 137-Cs to whole body doses of 0, 0.29, 1.0, 3.0, and 5.0 Gy. Glomerulopathy in the rats was measured using standard histological grading techniques on left kidney biopsy samples taken at times of one month prior to and three, six and nine months after irradiation. Twelve months after irradiation, both right and left kidneys were graded for the degree of glomerulopathy. A pilot tubular attributes study of the histologic samples was added in which eight attributes of tubular histopathology were scored for the degree of severity. The acute effects of radiation on hemopoiesis were studied in the 0, 0.29, 1.0, 3.0, and 5.0 Gy rats, and dose levels of 7.0 and 8.5 Gy were added to extend the dose range of the hemopoiesis study only. The factors of diabetes, irradiation, time after irradiation and the interactions of these factors did not significantly affect glomerulopathy in the rats. Radiation also was not a significant factor in the tubular attribute study. The results of this study imply that diabetic radiation workers are not at a significantly increased risk of nephropathy as a result of ionizing radiation exposure.
- Research Organization:
- Northwestern Univ., Evanston, IL (USA)
- OSTI ID:
- 5123226
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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DIABETES MELLITUS
PATHOLOGY
GLOMERULI
BIOLOGICAL RADIATION EFFECTS
UROGENITAL SYSTEM DISEASES
BIOLOGICAL MODELS
CESIUM 137
EXPERIMENTAL DATA
RATS
STREPTOZOCIN
WHOLE-BODY IRRADIATION
ALKALI METAL ISOTOPES
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CESIUM ISOTOPES
DATA
DISEASES
DRUGS
ENDOCRINE DISEASES
EXTERNAL IRRADIATION
INFORMATION
IRRADIATION
ISOTOPES
KIDNEYS
MAMMALS
METABOLIC DISEASES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
RADIATION EFFECTS
RADIOISOTOPES
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals