Osteonecrosis in patients with malignant lymphoma. A review of 31 cases

Journal Article · Mon Sep 01 00:00:00 EDT 1986 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19860901)58:5<1112::AID-CNCR2820580522>3.0.CO;2-B· OSTI ID:5119757

Rossleigh, M A; Smith, J; Straus, D J; Engel, I A

Osteonecrosis of the femoral and humeral heads is a serious complication of therapy for Hodgkin's disease and non-Hodgkin's lymphoma. Twenty-five patients were reassessed 5 years after being initially reported, in order to study the further progress and natural history of this complication. In addition, six recent patients who have also developed this condition are presented. With 5-year additional follow-up, no patient had developed symptoms of osteonecrosis in any bone other than those initially involved. Five patients developed severe complications thought to arise from their therapy suggesting that this group of patients were more sensitive to radiation injury than other patients treated with this modality. During the relatively short follow-up 5-year period, a surprising finding was the fact that 31% of the patients with Hodgkin's disease and 50% with non-Hodgkin's lymphoma had died. It is recommended that patients treated for lymphoma with steroid containing chemotherapy and radiotherapy be observed carefully for the occurrence of joint pain. Early diagnosis should lead to attempts to prevent total joint destruction.

• Research Organization: Memorial Sloan-Kettering Cancer Center, New York, NY
• OSTI ID: 5119757
• Journal Information: Cancer (Philadelphia); (United States), Vol. 5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
HODGKINS DISEASE
RADIOTHERAPY
SIDE EFFECTS
BONE JOINTS
LEGS
LYMPHOMAS
OSTEORADIONECROSIS
PATIENTS
SKELETON
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DISEASES
INJURIES
LIMBS
LOCAL RADIATION EFFECTS
MEDICINE
NECROSIS
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
SKELETAL DISEASES
THERAPY
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