Lung damage and pulmonary uptake of serotonin in intact dogs
The authors examined the influence of glass bead embolization and oleic acid, dextran, and imipramine infusion on the pulmonary uptake of trace doses of (/sup 3/H)serotonin and the extravascular volume accessible to (/sup 14/C)antipyrine in anesthetized dogs. Embolization and imipramine decreased serotonin uptake by 53 and 61%, respectively, but no change was observed with oleic acid or dextran infusion. The extravascular volume accessible to the antipyrine was reduced by 77% after embolization and increased by 177 and approximately 44% after oleic acid and dextran infusion, respectively. The results suggest that when the perfused endothelial surface is sufficiently reduced, as with embolization, the uptake of trace doses of serotonin will be depressed. In addition, decreases in serotonin uptake in response to imipramine in this study and in response to certain endothelial toxins in other studies suggest that serotonin uptake can reveal certain kinds of changes in endothelial function. However, the lack of a response to oleic acid-induced damage in the present study suggests that serotonin uptake is not sensitive to all forms of endothelial damage.
- Research Organization:
- Veterans Administration Medical Center, Wood, WI
- OSTI ID:
- 5118909
- Journal Information:
- J. Appl. Physiol.; (United States), Vol. 6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
DEXTRAN
BIOLOGICAL EFFECTS
IMIPRAMINE
TOXICITY
LUNGS
INJURIES
OLEIC ACID
SEROTONIN
UPTAKE
ANTIPYRINE
CARBON 14 COMPOUNDS
DOGS
ENDOTHELIUM
EXTRACELLULAR SPACE
INDOCYANINE GREEN
RESPIRATORY SYSTEM DISEASES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AMINES
ANIMAL TISSUES
ANIMALS
ANTIDEPRESSANTS
ANTIPYRETICS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BLOOD SUBSTITUTES
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CONDENSED AROMATICS
DISEASES
DRUGS
DYES
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDICATORS
INDOLES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MONOCARBOXYLIC ACIDS
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
POLYSACCHARIDES
PSYCHOTROPIC DRUGS
PYRAZOLES
PYRAZOLINES
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
SACCHARIDES
SPACE
SULFONATES
SYMPATHOMIMETICS
TISSUES
TRYPTAMINES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550501 - Metabolism- Tracer Techniques