Fetal translocation and metabolism of PAH obtained from coal fly ash given intratracheally to pregnant rats
Polycyclic aromatic hydrocarbons (PAH) were extracted from coal fly ash collected from the electrostatic precipitator of a thermal power plant. The PAH extract was given intratracheally daily to pregnant rats (2 mg/100 g body weight) on d 18 and 19 of gestation. In addition of d 19 of gestation rats were also given (/sup 4/H)benzo(a)pyrene intratracheally. Rats were sacrificed on d 20 of gestation, and the distribution of (/sup 3/H)benzo(a)pyrene radioactivity and PAH of coal fly ash was studied in maternal lung, liver, and placenta, as well as in the liver and lung of the fetus. The radioactivity of intratracheally given benzo(a)pyrene was found in liver (68%), placenta (4%), fetal lung (1.9%), and fetal liver (1.4%) of maternal lung. Intratracheally administered PAH of coal fly ash were translocated to maternal liver and placenta, as well as to the liver and lung of the fetus. PAH of coal fly ash were also metabolized to several minor and major metabolites by maternal lung, liver, and placenta, as well as by the maternal fetal liver and lung. Some of the PAH metabolites in lung and liver were common; however, the major metabolite of liver, M-16, was different from the major metabolite M-16 of lung. The major PAH metabolite of placenta, M-15, and fetal liver, F-12, were common PAH metabolites. M-2 and M-6 of the placenta and F-5 and F-10 of the fetal lung were also common.
- Research Organization:
- Univ. of Delhi, India
- OSTI ID:
- 5115999
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 18:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
FETUSES
CONTAMINATION
METABOLITES
COMPARATIVE EVALUATIONS
POLYCYCLIC AROMATIC HYDROCARBONS
MEMBRANE TRANSPORT
METABOLISM
TISSUE DISTRIBUTION
THERMAL POWER PLANTS
FLY ASH
COAL
ELECTROSTATIC PRECIPITATORS
EXPERIMENTAL DATA
FETAL MEMBRANES
INTRATRACHEAL ADMINISTRATION
LIVER
LUNGS
RATS
AEROSOL WASTES
ANIMALS
AROMATICS
ASHES
BODY
CARBONACEOUS MATERIALS
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
ENERGY SOURCES
EQUIPMENT
FOSSIL FUELS
FUELS
GLANDS
HYDROCARBONS
INFORMATION
MAMMALS
MATERIALS
MEMBRANES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
POLLUTION CONTROL EQUIPMENT
POWER PLANTS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
WASTES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)