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Title: Site-selective hydrolysis of tRNA by lanthanide metal complexes

tRNA[sup Phe] is site-selectively hydrolyzed by lanthanide metal complexes (Ce(III), Eu(III), La(III)) of hexaimine macrocyclic ligands. The selectivities of the complexes are much higher than those of the metal ions and are strongly dependent on the ligand structure. The tertiary structure of tRNA is essential for the site-selective scission.
Authors:
 [1] ; ; ; ;  [2] ;  [3]
  1. (Tokyo Institute of Technology, Yokohama (Japan))
  2. (Univ. of Tokyo (Japan))
  3. (Univ. of Tsukuba, Ibaraki (Japan))
Publication Date:
OSTI Identifier:
5110094
Resource Type:
Journal Article
Resource Relation:
Journal Name: Inorganic Chemistry; (United States); Journal Volume: 32:26
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; CERIUM COMPLEXES; CATALYTIC EFFECTS; EUROPIUM COMPLEXES; LANTHANUM COMPLEXES; TRANSFER RNA; HYDROLYSIS; CHELATES; ORGANIC NITROGEN COMPOUNDS; CHEMICAL REACTIONS; COMPLEXES; DECOMPOSITION; LYSIS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; RARE EARTH COMPLEXES; RNA; SOLVOLYSIS 400201* -- Chemical & Physicochemical Properties