Effects of 0. 12 and 0. 80 ppm ozone on rat nasal and nasopharyngeal epithelial mucosubstances: Quantitative histochemistry

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Toxicologic Pathology; (USA)

OSTI ID:5098921

Harkema, J R; Hotchkiss, J A; Henderson, R F ^[1]

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1. Inhalation Toxicology Research Institute, Albuquerque, NM (USA)

The present study was designed to characterize the quantity of mucosubstances in surface epithelia of the rat nasal cavity and nasopharynx after short-term ozone exposure. Rats were exposure. Nasal cavities were processed for morphometric analysis of intraepithelial mucosubstances. Compared to controls, rats exposed to 0.12 ppm ozone had increased amounts of stored mucosubstances within epithelium lining the medial aspect of the nasal turbinate, but no change within the epithelium of the nasopharynx. Rats exposed to 0.8 ppm ozone had increased quantities of stored mucosubstances within the transitional and respiratory epithelia lining turbinates and lateral walls of the anterior nasal airway, and significant decreases in stored mucosubstances within the epithelium of the nasal septum at the end of exposure. Seven days after the end of exposure, the amounts of intraepithelial mucosubstances returned to control levels along the septum, but remained greater than those of controls along the turbinates and nasopharynx. We conclude that exposures to ambient levels of ozone induce significant changes in the stored secretory product of nasal epithelium in the rat, and that these changes persist for at least 7 days after cessation of exposure.

• OSTI ID: 5098921
• Journal Information: Toxicologic Pathology; (USA), Vol. 17:3; ISSN 0192-6233
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MUCOUS MEMBRANES
SENSITIVITY
OZONE
TOXICITY
EPITHELIUM
NOSE
PATHOLOGICAL CHANGES
PHARYNX
RATS
ANIMAL TISSUES
ANIMALS
BODY
BODY AREAS
DIGESTIVE SYSTEM
FACE
HEAD
MAMMALS
MEMBRANES
ORGANS
RESPIRATORY SYSTEM
RODENTS
TISSUES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology