Regional myocardial blood flow in man during dipyridamole coronary vasodilation

Journal Article · Sat Jun 01 00:00:00 EDT 1985 · Chest; (United States)

DOI:https://doi.org/10.1378/chest.87.6.735· OSTI ID:5096812

Sorensen, S G; Groves, B M; Horwitz, L D; Chaudhuri, T K

Regional myocardial blood flow before and after intravenous dipyridamole (0.56 mg/kg) was measured during cardiac catheterization in 11 patients using the /sup 133/Xe washout technique. Significant increases in heart rate and decreases in systolic blood pressure were observed with dipyridamole infusion. However, double product and cardiac output did not differ before or after drug infusion. Regional myocardial blood flow increased from 67 to 117 ml/100 mg/min in myocardial segments supplied by nonobstructed coronary arteries. In stenotic coronary arteries, flow increased from 57 to 79 ml/100 mg/min with dipyridamole. We conclude that dipyridamole infusion results in flow differences which discriminate stenotic from nonstenotic coronary arteries.

• OSTI ID: 5096812
• Journal Information: Chest; (United States), Vol. 6
• Country of Publication: United States
• Language: English

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CORONARIES
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VASODILATORS
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