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Title: Heteronuclear three-dimensional NMR spectroscopy. Natural abundance sup 13 C chemical shift editing of sup 1 H- sup 1 H COSY spectra

Abstract

It has been demonstrated that heteronuclear 3D NMR spectroscopy can be effectively applied to small molecules with {sup 13}C at natural abundance. A 78mM solution of the aminoglycoside, kanamycin A was used for this experiment. The heteronuclear 3D NMR spectroscopy is shown to be a useful method for resolving spectral overlap in all frequency domains. 10 refs., 2 figs.

Authors:
; ;  [1]
  1. Abbott Labs., Abbott Park, IL (USA)
Publication Date:
OSTI Identifier:
5092804
Resource Type:
Journal Article
Journal Name:
Journal of the American Chemical Society; (USA)
Additional Journal Information:
Journal Volume: 111:2; Journal ID: ISSN 0002-7863
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; CARBON 13; ABUNDANCE; CHEMICAL SHIFT; NMR SPECTRA; CARBON ISOTOPES; EVEN-ODD NUCLEI; ISOTOPES; LIGHT NUCLEI; NUCLEI; SPECTRA; STABLE ISOTOPES; 400201* - Chemical & Physicochemical Properties; 400202 - Isotope Effects, Isotope Exchange, & Isotope Separation

Citation Formats

Fesik, S W, Gampe, Jr, R T, and Zuiderweg, E R.P. Heteronuclear three-dimensional NMR spectroscopy. Natural abundance sup 13 C chemical shift editing of sup 1 H- sup 1 H COSY spectra. United States: N. p., 1989. Web. doi:10.1021/ja00184a077.
Fesik, S W, Gampe, Jr, R T, & Zuiderweg, E R.P. Heteronuclear three-dimensional NMR spectroscopy. Natural abundance sup 13 C chemical shift editing of sup 1 H- sup 1 H COSY spectra. United States. https://doi.org/10.1021/ja00184a077
Fesik, S W, Gampe, Jr, R T, and Zuiderweg, E R.P. 1989. "Heteronuclear three-dimensional NMR spectroscopy. Natural abundance sup 13 C chemical shift editing of sup 1 H- sup 1 H COSY spectra". United States. https://doi.org/10.1021/ja00184a077.
@article{osti_5092804,
title = {Heteronuclear three-dimensional NMR spectroscopy. Natural abundance sup 13 C chemical shift editing of sup 1 H- sup 1 H COSY spectra},
author = {Fesik, S W and Gampe, Jr, R T and Zuiderweg, E R.P.},
abstractNote = {It has been demonstrated that heteronuclear 3D NMR spectroscopy can be effectively applied to small molecules with {sup 13}C at natural abundance. A 78mM solution of the aminoglycoside, kanamycin A was used for this experiment. The heteronuclear 3D NMR spectroscopy is shown to be a useful method for resolving spectral overlap in all frequency domains. 10 refs., 2 figs.},
doi = {10.1021/ja00184a077},
url = {https://www.osti.gov/biblio/5092804}, journal = {Journal of the American Chemical Society; (USA)},
issn = {0002-7863},
number = ,
volume = 111:2,
place = {United States},
year = {Wed Jan 18 00:00:00 EST 1989},
month = {Wed Jan 18 00:00:00 EST 1989}
}