skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: MEG-based imaging of focal neuronal current sources

Abstract

The authors describe a new approach to imaging neural current sources from measurements of the magnetoencephalogram (MEG) associated with sensory, motor, or cognitive brain activation. Many previous approaches to this problem have concentrated on the use of weighted minimum norm (WMN) inverse methods. While these methods ensure a unique solution, they do not introduce information specific to the MEG inverse problem, often producing overly smoothed solutions and exhibiting severe sensitivity to noise. The authors describe a Bayesian formulation of the inverse problem in which a Gibbs prior is constructed to reflect the sparse focal nature of neural current sources associated with evoked response data. They demonstrate the method with simulated and experimental phantom data, comparing its performance with several WMN methods.

Authors:
;  [1];  [2]
  1. Univ. of Southern California, Los Angeles, CA (United States). Signal and Image Processing Inst.
  2. Los Alamos National Lab., NM (United States)
Publication Date:
Sponsoring Org.:
National Eye Inst., Bethesda, MD (United States); Los Alamos National Lab., NM (United States)
OSTI Identifier:
509264
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Journal Article
Journal Name:
IEEE Transactions on Medical Imaging
Additional Journal Information:
Journal Volume: 16; Journal Issue: 3; Other Information: PBD: Jun 1997
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; IMAGE PROCESSING; MAGNETOMETERS; PHANTOMS; PERFORMANCE; BRAIN; NERVE CELLS

Citation Formats

Phillips, J W, Leahy, R M, and Mosher, J C. MEG-based imaging of focal neuronal current sources. United States: N. p., 1997. Web. doi:10.1109/42.585768.
Phillips, J W, Leahy, R M, & Mosher, J C. MEG-based imaging of focal neuronal current sources. United States. https://doi.org/10.1109/42.585768
Phillips, J W, Leahy, R M, and Mosher, J C. 1997. "MEG-based imaging of focal neuronal current sources". United States. https://doi.org/10.1109/42.585768.
@article{osti_509264,
title = {MEG-based imaging of focal neuronal current sources},
author = {Phillips, J W and Leahy, R M and Mosher, J C},
abstractNote = {The authors describe a new approach to imaging neural current sources from measurements of the magnetoencephalogram (MEG) associated with sensory, motor, or cognitive brain activation. Many previous approaches to this problem have concentrated on the use of weighted minimum norm (WMN) inverse methods. While these methods ensure a unique solution, they do not introduce information specific to the MEG inverse problem, often producing overly smoothed solutions and exhibiting severe sensitivity to noise. The authors describe a Bayesian formulation of the inverse problem in which a Gibbs prior is constructed to reflect the sparse focal nature of neural current sources associated with evoked response data. They demonstrate the method with simulated and experimental phantom data, comparing its performance with several WMN methods.},
doi = {10.1109/42.585768},
url = {https://www.osti.gov/biblio/509264}, journal = {IEEE Transactions on Medical Imaging},
number = 3,
volume = 16,
place = {United States},
year = {Sun Jun 01 00:00:00 EDT 1997},
month = {Sun Jun 01 00:00:00 EDT 1997}
}