Influence of copper and iron on subacute cadmium intoxication in protein-malnourished rats

Journal Article · Wed Oct 01 00:00:00 EDT 1986 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(86)80167-0· OSTI ID:5089385

Tewari, P C; Kachru, D N; Tandon, S K

Male albino rats maintained on low-protein (9%) diets were dosed intraperitoneally with 0.75 mg Cd/kg, as cadmium chloride, for 20 days. Groups of these animals were provided with diets supplemented with 40 ppm Cu, 400 ppm Fe or a combination of both during the exposure period. Hepatic and renal distribution of Cd, Zn, Cu, and Fe along with activity of acid and alkaline phosphatases and ribonuclease and glutathione content were studied. Uptake of Cd both in liver and in kidney was significant and was accompanied by increased Zn and depletion of Fe concentration. The Cu level remained unaltered. Dietary supplementation of Cu or Fe interacted effectively and influenced the metal distribution. Acid and alkaline phosphatases in both liver and kidney were inhibited by Cd exposure. However, Cu and/or Fe supplements could to a varying degree offset the Cd-induced inhibition. Cadmium exposure did not, however, elicit any effect on hepatic and renal ribonuclease activity of low-protein-fed animals. The glutathione concentration registered profound increase on Cd exposure, possibly to act as a defense mechanism.

• Research Organization: Industrial Toxicology Research Centre, Lucknow, India
• OSTI ID: 5089385
• Journal Information: Environ. Res.; (United States), Vol. 41:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
TISSUE DISTRIBUTION
TOXICITY
UPTAKE
COPPER
RESPONSE MODIFYING FACTORS
IRON
ZINC
ACID PHOSPHATASE
ALKALINE PHOSPHATASE
DIET
ENZYME ACTIVITY
EXPERIMENTAL DATA
GLUTATHIONE
INHIBITION
INTRAPERITONEAL INJECTION
KIDNEYS
LIVER
NUTRITIONAL DEFICIENCY
PROTEINS
RATS
RNA-ASE
ANIMALS
BODY
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELEMENTS
ENZYMES
ESTERASES
GLANDS
HYDROLASES
INFORMATION
INJECTION
INTAKE
MAMMALS
METALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
PHOSPHATASES
PHOSPHODIESTERASES
POLYPEPTIDES
RADIOPROTECTIVE SUBSTANCES
RODENTS
TRANSITION ELEMENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)