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Title: Sex and age differences in mercury distribution and excretion in methylmercury-administered mice

Abstract

Sex differences in mercury distribution and excretion after single administration of methylmercury chloride (MMC, 5 mg/kg were studied in mice. A sex difference in urinary mercury excretion was found in sexually mature mice (age of 7 wk) of C57BL/6N and BALB/cA strains. Males showed higher mercury levels in urine than females, though no significant difference was found in fecal mercury levels 24 h post exposure to MMC. The higher urinary excretion rates in males accounted for significant lowering of mercury levels in the brain, liver, and blood, but not in the kidney, which showed higher values. At 5 min, however, the sex difference was found only in the kidney, showing higher levels in males. Changes in mercury distribution with time were studied in C57BL/6N mice. The brain mercury increased in both sexes up to 3 d, and decreased only in males on d 5. Liver and blood mercury decreased with time in both sexes, and these were constantly higher in females than in males. Renal mercury in males decreased to similar levels to females on d 3. The sex differences at various ages were studied with C57BL/6N mice 24 h after dosing. Two-week-old mice did not show significant sex differencesmore » in the mercury distribution and excretion, and their urinary mercury levels were much lower as compared to the older mice. Urinary mercury excretion in both sexes increased at 4 wk of age and then decreased at 45 wk of age. At 4, 7, 10, and 45 wk of age, males showed higher urinary mercury levels than females. From these findings, it has been suggested that urinary mercury excretion may be related to sex hormones, especially androgens.« less

Authors:
;
Publication Date:
Research Org.:
National Institute for Minamata Disease, Minamata City, Japan
OSTI Identifier:
5088758
Resource Type:
Journal Article
Journal Name:
J. Toxicol. Environ. Health; (United States)
Additional Journal Information:
Journal Volume: 18:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MERCURY; RETENTION; TISSUE DISTRIBUTION; METHYLMERCURY; SINGLE INTAKE; AGE DEPENDENCE; BLOOD; BRAIN; EXPERIMENTAL DATA; FECES; KIDNEYS; LIVER; MERCURY CHLORIDES; MICE; SEX DEPENDENCE; URINE; ANIMALS; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; BODY FLUIDS; CENTRAL NERVOUS SYSTEM; CHLORIDES; CHLORINE COMPOUNDS; DATA; DIGESTIVE SYSTEM; DISTRIBUTION; ELEMENTS; GLANDS; HALIDES; HALOGEN COMPOUNDS; INFORMATION; INTAKE; MAMMALS; MATERIALS; MERCURY COMPOUNDS; MERCURY HALIDES; METALS; NERVOUS SYSTEM; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANIC MERCURY COMPOUNDS; ORGANS; RODENTS; VERTEBRATES; WASTES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Hirayama, K, and Yasutake, A. Sex and age differences in mercury distribution and excretion in methylmercury-administered mice. United States: N. p., 1986. Web. doi:10.1080/15287398609530847.
Hirayama, K, & Yasutake, A. Sex and age differences in mercury distribution and excretion in methylmercury-administered mice. United States. https://doi.org/10.1080/15287398609530847
Hirayama, K, and Yasutake, A. 1986. "Sex and age differences in mercury distribution and excretion in methylmercury-administered mice". United States. https://doi.org/10.1080/15287398609530847.
@article{osti_5088758,
title = {Sex and age differences in mercury distribution and excretion in methylmercury-administered mice},
author = {Hirayama, K and Yasutake, A},
abstractNote = {Sex differences in mercury distribution and excretion after single administration of methylmercury chloride (MMC, 5 mg/kg were studied in mice. A sex difference in urinary mercury excretion was found in sexually mature mice (age of 7 wk) of C57BL/6N and BALB/cA strains. Males showed higher mercury levels in urine than females, though no significant difference was found in fecal mercury levels 24 h post exposure to MMC. The higher urinary excretion rates in males accounted for significant lowering of mercury levels in the brain, liver, and blood, but not in the kidney, which showed higher values. At 5 min, however, the sex difference was found only in the kidney, showing higher levels in males. Changes in mercury distribution with time were studied in C57BL/6N mice. The brain mercury increased in both sexes up to 3 d, and decreased only in males on d 5. Liver and blood mercury decreased with time in both sexes, and these were constantly higher in females than in males. Renal mercury in males decreased to similar levels to females on d 3. The sex differences at various ages were studied with C57BL/6N mice 24 h after dosing. Two-week-old mice did not show significant sex differences in the mercury distribution and excretion, and their urinary mercury levels were much lower as compared to the older mice. Urinary mercury excretion in both sexes increased at 4 wk of age and then decreased at 45 wk of age. At 4, 7, 10, and 45 wk of age, males showed higher urinary mercury levels than females. From these findings, it has been suggested that urinary mercury excretion may be related to sex hormones, especially androgens.},
doi = {10.1080/15287398609530847},
url = {https://www.osti.gov/biblio/5088758}, journal = {J. Toxicol. Environ. Health; (United States)},
number = ,
volume = 18:1,
place = {United States},
year = {Wed Jan 01 00:00:00 EST 1986},
month = {Wed Jan 01 00:00:00 EST 1986}
}