skip to main content

Title: Effect of MSH/ACTH peptides on fast axonal transport in intact and regenerating sciatic nerves

Fast axonal transport was examined in intact rats treated with ACTH 4-10 or ACTH 4-9 (ORG 2766), hypophysectomized rats, adrenalectomized rats, and in ACTH 4-10 treated rats with crushed regenerating sciatic nerves by injecting /sup 3/H-leucine into the ventral horn region of the spinal cord. The distance traveled by the transported activity along the sciatic nerve and the rate of fast axonal transport were not significantly altered as a result of treatment with ACTH 4-10, ACTH 4-9 (ORG 2766), hypophysectomy, or adrenalectomy. Treatment with ACTH 4-9 (ORG 2766) at concentrations of 1 ..mu..g/Kg /day and 10 ..mu..g/Kg/day caused significant reductions (62% and 64% respectively) in the crest height of the fast axonal transport curve as compared to 0.9% saline treated control animals. No significant differences were found in comparing the distance, rate, slope, or crest height of ACTH 4-10 treated animals with crushed regenerating (7 or 14d) sciatic nerves to control animals. In the group of animals in days, the amount of radiolabeled activity was significantly increased in the ACTH 4-10 treated animals as compared to control animals. The results indicate that during regeneration the peptide acts to prolong the initially high levels of synthetic activity which occur in regeneratingmore » axons.« less
Authors:
Publication Date:
OSTI Identifier:
5071491
Resource Type:
Thesis/Dissertation
Resource Relation:
Other Information: Thesis (Ph. D.)
Publisher:
New York Univ.,New York, NY
Research Org:
New York Univ., NY (USA)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ACTH; BIOLOGICAL EFFECTS; SCIATIC NERVE; RADIONUCLIDE KINETICS; ADRENALECTOMY; BIOELECTRICITY; BIOLOGICAL REGENERATION; HYPOPHYSECTOMY; LEUCINE; RATS; TRITIUM COMPOUNDS; AMINO ACIDS; ANIMALS; BIOLOGICAL RECOVERY; CARBOXYLIC ACIDS; ELECTRICITY; HORMONES; LABELLED COMPOUNDS; MAMMALS; MEDICINE; NERVES; NERVOUS SYSTEM; ORGANIC ACIDS; ORGANIC COMPOUNDS; PEPTIDE HORMONES; PITUITARY HORMONES; RECOVERY; RODENTS; SURGERY; VERTEBRATES 560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)