Toxicity, distribution, and elimination of thiol complexes of methylmercury after intracerebral injection

Journal Article · Wed Jan 01 00:00:00 EST 1986 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398609530922· OSTI ID:5070999

Fair, P H; Balthrop, J E; Wade, J L; Braddon-Galloway, S

Intracerebral injection of CH/sub 3/Hg and CH/sub 3/Hg complexed with glutathione (GSH), cysteine (cys), cysteinylglycine (cys-gly), and homocysteine (homocys) resulted in differences in toxicity. Criteria based on neurological indices, mortality, and weight loss indicated that the cys-gly complex of CH/sub 3/Hg was significantly less toxic than CH/sub 3/Hg or the other complexes. The other complexes of CH/sub 3/Hg (GSH, homocys, and cys) were also found to be less toxic than CH/sub 3/Hg. The selenium status of the animal did not seem to significantly influence the toxicity of CH/sub 3/Hg and the complexes. While CH/sub 3/Hg complexed to cys-gly was significantly less toxic than CH/sub 3/Hg alone, there were no differences observed in the CH/sub 3/Hg half-life values or in the distribution of these compounds in the kidneys, brain, liver, and blood. It was observed, however, that the CH/sub 3/Hg-cys-gly complex had higher fecal excretion on d 3 and 4 following intracerebral injection.

• Research Organization: National Marine Fisheries Service, Charleston, SC
• OSTI ID: 5070999
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 19:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CYSTEINE
RESPONSE MODIFYING FACTORS
GLUTATHIONE
HOMOCYSTEINE
METHYLMERCURY
RETENTION
TISSUE DISTRIBUTION
TOXICITY
BIOLOGICAL HALF-LIFE
BLOOD
BRAIN
CEREBRUM
COMPLEXES
EXPERIMENTAL DATA
INJECTION
KIDNEYS
LABORATORY ANIMALS
LIVER
MORTALITY
SELENIUM
WEIGHT
AMINO ACIDS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELEMENTS
GLANDS
INFORMATION
INTAKE
MATERIALS
MERCURY COMPOUNDS
NERVOUS SYSTEM
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
SEMIMETALS
THIOLS
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)