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Title: Reduced tar, nicotine, and carbon monoxide exposure while smoking ultralow- but not low-yield cigarettes

An unresolved public health issue is whether some modern cigarettes are less hazardous than other and whether patients who cannot stop smoking should be advised to switch to lower-yield cigarettes. The authors studied tar (estimated by urine mutagenicity), nicotine, and carbon monoxide exposure in habitual smokers switched from their usual brand to high- (15 mg of tar), low- (5 mg of tar), or ultralow-yield (1 mg of tar) cigarettes. There were no differences in exposure comparing high- or low-yield cigarettes, but tar and nicotine exposures were reduced by 49% and 56%, respectively, and carbon monoxide exposure by 36% while smoking ultralow-yield cigarettes. Similarly, in 248 subjects smoking their self-selected brand, nicotine intake, estimated by blood concentrations of its metabolite continine, was 40% lower in those who smoked ultralow but no different in those smoking higher yields of cigarettes. The data indicate that ultralow-yield cigarettes do deliver substantial doses of tar, nicotine, and carbon monoxide, but that exposure are considerably less than for other cigarettes.
Authors:
; ; ; ; ;
Publication Date:
OSTI Identifier:
5070819
Resource Type:
Journal Article
Resource Relation:
Journal Name: JAMA, J. Am. Med. Assoc.; (United States); Journal Volume: 256:2
Research Org:
San Francisco General Hospital Medical Center, CA
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; NICOTINE; BLOOD CHEMISTRY; TOBACCO PRODUCTS; EVALUATION; TOBACCO SMOKES; BIOLOGICAL EFFECTS; CARBON MONOXIDE; METABOLITES; PATIENTS; PUBLIC HEALTH; TAR; URINE; AEROSOLS; ALKALOIDS; AMINES; AUTONOMIC NERVOUS SYSTEM AGENTS; AZINES; AZOLES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY FLUIDS; CARBON COMPOUNDS; CARBON OXIDES; CHALCOGENIDES; COLLOIDS; DISPERSIONS; DRUGS; HETEROCYCLIC COMPOUNDS; MATERIALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; OTHER ORGANIC COMPOUNDS; OXIDES; OXYGEN COMPOUNDS; PARASYMPATHOLYTICS; PARASYMPATHOMIMETICS; PYRIDINES; PYRROLES; PYRROLIDINES; RESIDUES; SMOKES; SOLS; WASTES 560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)