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Title: Thyroid neoplasia following low-dose radiation in childhood

Abstract

The thyroid gland is highly sensitive to the carcinogenic effects of ionizing radiation. Previously, we reported a significant increase of thyroid cancer and adenomas among 10,834 persons in Israel who received radiotherapy to the scalp for ringworm. These findings have now been extended with further follow-up and revised dosimetry. Overall, 98 thyroid tumors were identified among the exposed and 57 among 10,834 nonexposed matched population and 5392 sibling comparison subjects. An estimated thyroid dose of 9 cGy was linked to a fourfold (95% Cl = 2.3-7.9) increase of malignant tumors and a twofold (95% Cl = 1.3-3.0) increase of benign tumors. The dose-response relationship was consistent with linearity. Age was an important modifier of risk with those exposed under 5 years being significantly more prone to develop thyroid tumors than older children. The pattern of radiation risk over time could be described on the basis of a constant multiplication of the background rate, and an absolute risk model was not compatible with the observed data. Overall, the excess relative risk per cGy for thyroid cancer development after childhood exposure is estimated as 0.3, and the absolute excess risk as 13 per 10(6) PY-cGy. For benign tumors the estimated excess relativemore » risk was 0.1 per cGy and the absolute risk was 15 per 10(6) PY-cGy.« less

Authors:
; ; ; ; ;  [1]
  1. Chaim Sheba Medical Center, Tel Hashomer (Israel)
Publication Date:
OSTI Identifier:
5045057
Resource Type:
Journal Article
Journal Name:
Radiation Research; (USA)
Additional Journal Information:
Journal Volume: 120:3; Journal ID: ISSN 0033-7587
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; NEOPLASMS; RADIOINDUCTION; RADIOTHERAPY; SIDE EFFECTS; THYROID; DELAYED RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIPS; ISRAEL; LOW DOSE IRRADIATION; RISK ASSESSMENT; ASIA; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DEVELOPING COUNTRIES; DISEASES; ENDOCRINE GLANDS; GLANDS; IRRADIATION; MEDICINE; MIDDLE EAST; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIOLOGY; THERAPY; 560151* - Radiation Effects on Animals- Man

Citation Formats

Ron, E, Modan, B, Preston, D, Alfandary, E, Stovall, M, and Boice, Jr, J D. Thyroid neoplasia following low-dose radiation in childhood. United States: N. p., 1989. Web. doi:10.2307/3577801.
Ron, E, Modan, B, Preston, D, Alfandary, E, Stovall, M, & Boice, Jr, J D. Thyroid neoplasia following low-dose radiation in childhood. United States. https://doi.org/10.2307/3577801
Ron, E, Modan, B, Preston, D, Alfandary, E, Stovall, M, and Boice, Jr, J D. 1989. "Thyroid neoplasia following low-dose radiation in childhood". United States. https://doi.org/10.2307/3577801.
@article{osti_5045057,
title = {Thyroid neoplasia following low-dose radiation in childhood},
author = {Ron, E and Modan, B and Preston, D and Alfandary, E and Stovall, M and Boice, Jr, J D},
abstractNote = {The thyroid gland is highly sensitive to the carcinogenic effects of ionizing radiation. Previously, we reported a significant increase of thyroid cancer and adenomas among 10,834 persons in Israel who received radiotherapy to the scalp for ringworm. These findings have now been extended with further follow-up and revised dosimetry. Overall, 98 thyroid tumors were identified among the exposed and 57 among 10,834 nonexposed matched population and 5392 sibling comparison subjects. An estimated thyroid dose of 9 cGy was linked to a fourfold (95% Cl = 2.3-7.9) increase of malignant tumors and a twofold (95% Cl = 1.3-3.0) increase of benign tumors. The dose-response relationship was consistent with linearity. Age was an important modifier of risk with those exposed under 5 years being significantly more prone to develop thyroid tumors than older children. The pattern of radiation risk over time could be described on the basis of a constant multiplication of the background rate, and an absolute risk model was not compatible with the observed data. Overall, the excess relative risk per cGy for thyroid cancer development after childhood exposure is estimated as 0.3, and the absolute excess risk as 13 per 10(6) PY-cGy. For benign tumors the estimated excess relative risk was 0.1 per cGy and the absolute risk was 15 per 10(6) PY-cGy.},
doi = {10.2307/3577801},
url = {https://www.osti.gov/biblio/5045057}, journal = {Radiation Research; (USA)},
issn = {0033-7587},
number = ,
volume = 120:3,
place = {United States},
year = {Fri Dec 01 00:00:00 EST 1989},
month = {Fri Dec 01 00:00:00 EST 1989}
}