Noninvasive measurement of regional cerebral blood flow change with H[sub 2][sup 15]O and positron and emission tomography using a mechanical injector and a standard arterial input function

Journal Article · Wed Dec 01 00:00:00 EST 1993 · IEEE Transactions on Medical Imaging (Institute of Electrical and Electronics Engineers); (United States)

DOI:https://doi.org/10.1109/42.251121· OSTI ID:5043878

Sadato, Norihiro; Magata, Yasuhiro; Iwasaki, Yasushi; Matoba, Naoki; Tsuchida, Tatsuro; Tamaki, Nagara; Konishi, Junji ^[1]; Yonekura, Yoshiharu; Shibasaki, Hiroshi ^[2]; Senda, Michio ^[3]

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1. Kyoto Univ. Faculty of Medicine (Japan). Dept. of Nuclear Medicine
2. Kyoto Univ. Faculty of Medicine (Japan). Dept. of Brain Pathophysiology
3. Tokyo Metropolitan Inst. of Gerontology, Tokyo (Japan); and others

To estimate changes in regional cerebral blood flow (rCBF) without arterial sampling in the study of functional-anatomical correlations in the human brain, using [sup 15]O-labeled water and PET, a standard arterial input function was generated from the input function in 10 normal volunteers with dose calibration and peak time normalization. The speed and volume of injection were precisely controlled with a mechanical injector. After global normalization of each tissue activity image, the standard arterial input function was applied to obtain estimated CBF images. Relative changes in estimated rCBF to whole brain mean CBF([delta]Fest) and those in regional tissue activity ([delta]C) were compared with true relative rCBF changes ([delta]F) in 40 pairs of images obtained from 6 normal volunteers. [delta]Fest correlated well with [delta]F, whereas [delta]C consistently underestimated [delta]F. This noninvasive method simplifies the activation studies and provides the accurate estimation of relative flow changes.

• OSTI ID: 5043878
• Journal Information: IEEE Transactions on Medical Imaging (Institute of Electrical and Electronics Engineers); (United States), Vol. 12:4; ISSN 0278-0062
• Country of Publication: United States
• Language: English

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