Subacute and subchronic oral toxicity of p-chlorotoluene in the rat
P-Chlorotoluene was administered by gavage for 14 and 90 days to male and female Sprague-Dawley-derived rats at dose levels of 200, 600 and 1800 mg/kg/day and 50, 200 and 800 mg/kg/day, respectively. In the 14-day study 8 of 10 animals of each sex in the high-dose group died due to treatment. Other treatment-related signs for these animals included an adverse effect upon body weight, and clinical signs of salivation, tremors and prostration. In the 200 and 600 mg/kg/day groups there were no apparent treatment-related effects. In the 90-day study, 4 of 10 males and 2 of 10 females in the high-dose group died due to treatment. Other signs for this treatment group included an adverse effect upon body weight, and clinical signs of languid behavior, prostration, tremors, sensitive to touch, epistaxis and respiratory distress. Increases in alkaline phosphatase and creatinine (males only), and increases in adrenal (absolute and relative, females), kidney (relative, both sexes) and liver (relative, both sexes) weights were also noted.
- Research Organization:
- Hazleton Labs. America, Inc., Rockville, MD (United States)
- OSTI ID:
- 5032270
- Report Number(s):
- PB-91-233379/XAB; CNN: EPA-68-03-4008
- Resource Relation:
- Other Information: Pub. in Jnl. of American College of Toxicology, v9 n5 p487-495 Nov 90. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHLORINATED AROMATIC HYDROCARBONS
TOXICITY
ADRENAL GLANDS
ALKALINE PHOSPHATASE
CREATININE
DOSE-RESPONSE RELATIONSHIPS
KIDNEYS
LIVER
ORAL ADMINISTRATION
RATS
ANIMALS
AROMATICS
AZOLES
BODY
DIGESTIVE SYSTEM
ENDOCRINE GLANDS
ENZYMES
ESTERASES
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
HYDROLASES
IMIDAZOLES
IMINES
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHOSPHATASES
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology