skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Biological monitoring of arsenic exposure of gallium arsenide- and inorganic arsenic-exposed workers by determination of inorganic arsenic and its metabolites in urine and hair

Abstract

In an attempt to establish a method for biological monitoring of inorganic arsenic exposure, the chemical species of arsenic were measured in the urine and hair of gallium arsenide (GaAs) plant and copper smelter workers. Determination of urinary inorganic arsenic concentration proved sensitive enough to monitor the low-level inorganic arsenic exposure of the GaAs plant workers. The urinary inorganic arsenic concentration in the copper smelter workers was far higher than that of a control group and was associated with high urinary concentrations of the inorganic arsenic metabolites, methylarsonic acid (MAA) and dimethylarsinic acid (DMAA). The results established a method for exposure level-dependent biological monitoring of inorganic arsenic exposure. Low-level exposures could be monitored only by determining urinary inorganic arsenic concentration. High-level exposures clearly produced an increased urinary inorganic arsenic concentration, with an increased sum of urinary concentrations of inorganic arsenic and its metabolites (inorganic arsenic + MAA + DMAA). The determination of urinary arsenobetaine proved to determine specifically the seafood-derived arsenic, allowing this arsenic to be distinguished clearly from the arsenic from occupational exposure. Monitoring arsenic exposure by determining the arsenic in the hair appeared to be of value only when used for environmental monitoring of arsenic contamination rather thanmore » for biological monitoring.« less

Authors:
; ; ;  [1]
  1. St. Marianna Univ. School of Medicine, Kawasaki (Japan)
Publication Date:
OSTI Identifier:
5030496
Resource Type:
Journal Article
Journal Name:
American Industrial Hygiene Association Journal; (USA)
Additional Journal Information:
Journal Volume: 50:11; Journal ID: ISSN 0002-8894
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ARSENIC; METABOLISM; GALLIUM COMPOUNDS; HAIR; METABOLITES; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; PERSONNEL; WELDING; BODY; ELEMENTS; FABRICATION; JOINING; ORGANS; SEMIMETALS; SKIN; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Yamauchi, H, Takahashi, K, Mashiko, M, and Yamamura, Y. Biological monitoring of arsenic exposure of gallium arsenide- and inorganic arsenic-exposed workers by determination of inorganic arsenic and its metabolites in urine and hair. United States: N. p., 1989. Web. doi:10.1080/15298668991375236.
Yamauchi, H, Takahashi, K, Mashiko, M, & Yamamura, Y. Biological monitoring of arsenic exposure of gallium arsenide- and inorganic arsenic-exposed workers by determination of inorganic arsenic and its metabolites in urine and hair. United States. https://doi.org/10.1080/15298668991375236
Yamauchi, H, Takahashi, K, Mashiko, M, and Yamamura, Y. 1989. "Biological monitoring of arsenic exposure of gallium arsenide- and inorganic arsenic-exposed workers by determination of inorganic arsenic and its metabolites in urine and hair". United States. https://doi.org/10.1080/15298668991375236.
@article{osti_5030496,
title = {Biological monitoring of arsenic exposure of gallium arsenide- and inorganic arsenic-exposed workers by determination of inorganic arsenic and its metabolites in urine and hair},
author = {Yamauchi, H and Takahashi, K and Mashiko, M and Yamamura, Y},
abstractNote = {In an attempt to establish a method for biological monitoring of inorganic arsenic exposure, the chemical species of arsenic were measured in the urine and hair of gallium arsenide (GaAs) plant and copper smelter workers. Determination of urinary inorganic arsenic concentration proved sensitive enough to monitor the low-level inorganic arsenic exposure of the GaAs plant workers. The urinary inorganic arsenic concentration in the copper smelter workers was far higher than that of a control group and was associated with high urinary concentrations of the inorganic arsenic metabolites, methylarsonic acid (MAA) and dimethylarsinic acid (DMAA). The results established a method for exposure level-dependent biological monitoring of inorganic arsenic exposure. Low-level exposures could be monitored only by determining urinary inorganic arsenic concentration. High-level exposures clearly produced an increased urinary inorganic arsenic concentration, with an increased sum of urinary concentrations of inorganic arsenic and its metabolites (inorganic arsenic + MAA + DMAA). The determination of urinary arsenobetaine proved to determine specifically the seafood-derived arsenic, allowing this arsenic to be distinguished clearly from the arsenic from occupational exposure. Monitoring arsenic exposure by determining the arsenic in the hair appeared to be of value only when used for environmental monitoring of arsenic contamination rather than for biological monitoring.},
doi = {10.1080/15298668991375236},
url = {https://www.osti.gov/biblio/5030496}, journal = {American Industrial Hygiene Association Journal; (USA)},
issn = {0002-8894},
number = ,
volume = 50:11,
place = {United States},
year = {Wed Nov 01 00:00:00 EST 1989},
month = {Wed Nov 01 00:00:00 EST 1989}
}