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Title: Gender differences in age effect on brain atrophy measured by magnetic resonance imaging

A prospective sample of 69 healthy adults, age range 18-80 years, was studied with magnetic resonance imaging scans of the entire cranium. Volumes were obtained by a segmentation algorithm that uses proton density and T{sub 2} pixel values to correct field inhomogeneities (shading). Average ({plus minus}SD) brain volume, excluding cerebellum, was 1090.91 ml and cerebrospinal fluid (DSF) volume was 127.91 ml. Brain volume was higher (by 5 ml) in the right hemisphere. Men had 91 ml higher brain and 20 ml higher CSF volume than women. Age was negatively correlated with brain volume and positively correlated with CSF volume. The slope fo the regression line with age for CSF was steeper for men than women. This difference in slopes was significant for sulca but not ventricular, CSF. The greatest amount of atrophy in elderly men was in the left hemisphere, whereas is women age effects were symmetric. The findings may point to neuroanatomic substrates of hemispheric specialization and gender differences in age-related changes in brain function. They suggest that women are less vulnerable to age-related changes in mental abilities, whereas men are particularly susceptible to aging effects on left hemispheric functions.
Authors:
; ; ; ; ; ; ; ; ; ; ;  [1]
  1. (Univ. of Pennsylvania, Philadelphia (United States))
Publication Date:
OSTI Identifier:
5028198
Resource Type:
Journal Article
Resource Relation:
Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (United States); Journal Volume: 88:7
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; NUCLEAR MAGNETIC RESONANCE; CEREBROSPINAL FLUID; VOLUME; ADULTS; AGE DEPENDENCE; ATROPHY; SEX DEPENDENCE; AGE GROUPS; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CENTRAL NERVOUS SYSTEM; MAGNETIC RESONANCE; MATERIALS; NERVOUS SYSTEM; ORGANS; PATHOLOGICAL CHANGES; RESONANCE 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics