Applications of scanning electron microscopy and X-ray microanalysis in inner ear pathology

Journal Article · Tue Jan 01 00:00:00 EST 1985 · Scanning Electron Microsc.; (United States)

OSTI ID:5028080

Anniko, M; Lim, D J; Sobin, A; Wroblewski, R

Surface pathology of inner ear structures so far described in detail concern cochlear and vestibular hair cells and the stria vascularis. In man, surgical intervention into the inner ear is very uncommon and when performed is in general with the primary objective of destroying the diseased peripheral end organs. The vast majority of inner ear tissue available for use with scanning electron microscopy (SEM) is therefore obtained from animals. The present paper reviews the progression of surface pathology caused by aminoglycoside antibiotics, acoustic overstimulation and in a guinea pig strain with genetic inner ear disease. The primary site of onset of surface pathology differs, depending on the underlying cause. Advanced surface pathology shows a similar type of morphological degeneration independent of cause. The combination of SEM and energy dispersive X-ray microanalysis (XRMA) of inner ear pathology has as yet been reported in only three studies, all concerning inner ear fluids or otoconia.

• OSTI ID: 5028080
• Journal Information: Scanning Electron Microsc.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIBIOTICS
BIOLOGICAL EFFECTS
AUDITORY ORGANS
INJURIES
PATHOLOGY
NOISE
ELECTRON MICROPROBE ANALYSIS
GUINEA PIGS
HEREDITARY DISEASES
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MICROSCOPY
ORGANS
RODENTS
SENSE ORGANS
VERTEBRATES
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