Effects of intratumoral injection of I-125 iododeoxyuridine on Ehrlich ascites carcinoma
- Univ. of Medicine and Dentistry of New Jersey, Newark (USA)
Intratumoral injection of I-125 iododeoxyuridine (IUdR), saline solution, and oil suspension was investigated using Ehrlich ascites tumors in the thighs of mice. The oil suspension was more effective in tumor growth delay than was the saline solution. Single injection of the oil suspension at the dose of 12.5 microCi resulted in 21.5 days growth delay, whereas 50 microCi of the saline solution resulted in 11.5 days growth delay relative to control growth delay. At 40 days after treatment, higher radioactivities were observed in the tumor and the skin of the mice treated with the oil suspension, which represented the prolongation of I-125 IUdR oil suspension within the tumor. No normal tissue toxicities were observed.
- OSTI ID:
- 5026358
- Journal Information:
- Journal of Surgical Oncology; (USA), Vol. 42:3; ISSN 0022-4790
- Country of Publication:
- United States
- Language:
- English
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EHRLICH ASCITES TUMOR
RADIOIMMUNOTHERAPY
CARCINOMAS
DEOXYURIDINE
EXPERIMENTAL NEOPLASMS
INJECTION
IODINE 125
MICE
ANIMALS
ANTIMETABOLITES
AZINES
BETA DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMMUNOLOGY
IMMUNOTHERAPY
INTAKE
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIOIMMUNOLOGY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RIBOSIDES
RODENTS
THERAPY
URACILS
VERTEBRATES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)