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Title: Selected ultratrace elements in total parenteral nutrition solutions

Abstract

Ultratrace elements are potentially essential (eg. boron, molybdenum, nickel, and vanadium) or toxic (eg, aluminum and cadmium) in humans. Long-term total parenteral nutrition (TPN) patients can inadvertently receive significant amounts of ultratrace elements present as contaminants in TPN solutions. We determined the intake of selected ultratrace elements from a standard TPN solution and compared it with the amount reported to be absorbed from food in normal subjects. Contamination of TPN solutions with ultratrace elements was widespread and variable. The daily intakes of Mo, Ni, V. and Cd from this contamination were comparable to the amounts reported to be absorbed through the gastrointestinal tract in normal subjects. Al intake was high; B intake was low, approximately 10% of the amount absorbed by normal subjects. Thus, TPN solutions are contaminated with significant amounts of ultratrace elements. The biological significance of the intravenous infusion of these ultratrace elements is unclear and requires further investigation, particularly in home TPN patients.

Authors:
; ; ; ; ;  [1]
  1. Memorial Sloan-Kettering Cancer Center, New York, NY (USA)
Publication Date:
OSTI Identifier:
5024384
Resource Type:
Journal Article
Journal Name:
American Journal of Clinical Nutrition; (USA)
Additional Journal Information:
Journal Volume: 50:5; Journal ID: ISSN 0002-9165
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ALUMINIUM; TOXICITY; BORON; CADMIUM; MOLYBDENUM; NICKEL; VANADIUM; CONTAMINATION; INTESTINAL ABSORPTION; MAN; NUTRITION; PATIENTS; SPECTROPHOTOMETRY; TRACE AMOUNTS; ABSORPTION; ANIMALS; ELEMENTS; MAMMALS; METALS; PRIMATES; SEMIMETALS; TRANSITION ELEMENTS; UPTAKE; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Berner, Y N, Shuler, T R, Nielsen, F H, Flombaum, C, Farkouh, S A, and Shike, M. Selected ultratrace elements in total parenteral nutrition solutions. United States: N. p., 1989. Web.
Berner, Y N, Shuler, T R, Nielsen, F H, Flombaum, C, Farkouh, S A, & Shike, M. Selected ultratrace elements in total parenteral nutrition solutions. United States.
Berner, Y N, Shuler, T R, Nielsen, F H, Flombaum, C, Farkouh, S A, and Shike, M. 1989. "Selected ultratrace elements in total parenteral nutrition solutions". United States.
@article{osti_5024384,
title = {Selected ultratrace elements in total parenteral nutrition solutions},
author = {Berner, Y N and Shuler, T R and Nielsen, F H and Flombaum, C and Farkouh, S A and Shike, M},
abstractNote = {Ultratrace elements are potentially essential (eg. boron, molybdenum, nickel, and vanadium) or toxic (eg, aluminum and cadmium) in humans. Long-term total parenteral nutrition (TPN) patients can inadvertently receive significant amounts of ultratrace elements present as contaminants in TPN solutions. We determined the intake of selected ultratrace elements from a standard TPN solution and compared it with the amount reported to be absorbed from food in normal subjects. Contamination of TPN solutions with ultratrace elements was widespread and variable. The daily intakes of Mo, Ni, V. and Cd from this contamination were comparable to the amounts reported to be absorbed through the gastrointestinal tract in normal subjects. Al intake was high; B intake was low, approximately 10% of the amount absorbed by normal subjects. Thus, TPN solutions are contaminated with significant amounts of ultratrace elements. The biological significance of the intravenous infusion of these ultratrace elements is unclear and requires further investigation, particularly in home TPN patients.},
doi = {},
url = {https://www.osti.gov/biblio/5024384}, journal = {American Journal of Clinical Nutrition; (USA)},
issn = {0002-9165},
number = ,
volume = 50:5,
place = {United States},
year = {Wed Nov 01 00:00:00 EST 1989},
month = {Wed Nov 01 00:00:00 EST 1989}
}