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Title: Epidemiologic study on carcinoma of the breast following irradiation for benign conditions in infancy and childhood

Abstract

To investigate the relationship of irradiation during infancy and childhood to the subsequent development of carcinoma of the breast, 996 eligible patients were studied at Evanston Hospital, Evanston, Illinois, and Northwestern Memorial Hospital, Chicago. This was a case-control study, with those in the control group being selected from concurrent hospital admissions for nonmalignant surgical conditions. A second group consisting of those with benign biopsy results was also studied. The Mantel-Haenszel method of analysis, controlling for age and race, was used to estimate the approximate relative risk of carcinoma of the breast in the irradiated group compared with that for the nonirradiated group. The type of radiation history included radiotherapy for mastitis or enlarged thymus (nine patients), irradiation of the head and neck (69 patients), diagnostic fluoroscopies (ten patients) and miscellaneous irradiation (52 patients) for bursitis, eczema or keloid. Based upon the data obtained from the results of this study and its analysis, we conclude that there is little evidence of increased risk of carcinoma of the breast after irradiation about the head, neck and chest areas for benign conditions in the population being studied herein. Such a risk, if indeed it exists at all for this population, is estimated tomore » be about 10 per cent.« less

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Evanston Hospital, IL
OSTI Identifier:
5021935
Resource Type:
Journal Article
Journal Name:
Surg. Gynecol. Obstet.; (United States)
Additional Journal Information:
Journal Volume: 157:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARCINOMAS; RADIOINDUCTION; MAMMARY GLANDS; DELAYED RADIATION EFFECTS; RADIOTHERAPY; SIDE EFFECTS; EPIDEMIOLOGY; PATIENTS; RISK ASSESSMENT; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DISEASES; GLANDS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIOLOGY; THERAPY; 560151* - Radiation Effects on Animals- Man

Citation Formats

Oviedo, M A, Chmiel, J S, Curb, J D, Kautz, J A, Haenszel, W, and Scanlon, E F. Epidemiologic study on carcinoma of the breast following irradiation for benign conditions in infancy and childhood. United States: N. p., 1983. Web.
Oviedo, M A, Chmiel, J S, Curb, J D, Kautz, J A, Haenszel, W, & Scanlon, E F. Epidemiologic study on carcinoma of the breast following irradiation for benign conditions in infancy and childhood. United States.
Oviedo, M A, Chmiel, J S, Curb, J D, Kautz, J A, Haenszel, W, and Scanlon, E F. 1983. "Epidemiologic study on carcinoma of the breast following irradiation for benign conditions in infancy and childhood". United States.
@article{osti_5021935,
title = {Epidemiologic study on carcinoma of the breast following irradiation for benign conditions in infancy and childhood},
author = {Oviedo, M A and Chmiel, J S and Curb, J D and Kautz, J A and Haenszel, W and Scanlon, E F},
abstractNote = {To investigate the relationship of irradiation during infancy and childhood to the subsequent development of carcinoma of the breast, 996 eligible patients were studied at Evanston Hospital, Evanston, Illinois, and Northwestern Memorial Hospital, Chicago. This was a case-control study, with those in the control group being selected from concurrent hospital admissions for nonmalignant surgical conditions. A second group consisting of those with benign biopsy results was also studied. The Mantel-Haenszel method of analysis, controlling for age and race, was used to estimate the approximate relative risk of carcinoma of the breast in the irradiated group compared with that for the nonirradiated group. The type of radiation history included radiotherapy for mastitis or enlarged thymus (nine patients), irradiation of the head and neck (69 patients), diagnostic fluoroscopies (ten patients) and miscellaneous irradiation (52 patients) for bursitis, eczema or keloid. Based upon the data obtained from the results of this study and its analysis, we conclude that there is little evidence of increased risk of carcinoma of the breast after irradiation about the head, neck and chest areas for benign conditions in the population being studied herein. Such a risk, if indeed it exists at all for this population, is estimated to be about 10 per cent.},
doi = {},
url = {https://www.osti.gov/biblio/5021935}, journal = {Surg. Gynecol. Obstet.; (United States)},
number = ,
volume = 157:1,
place = {United States},
year = {Fri Jul 01 00:00:00 EDT 1983},
month = {Fri Jul 01 00:00:00 EDT 1983}
}