Synthesis of deuterium labeled 17-methyl-testosterone
Journal Article
·
· Steroids; (United States)
The synthesis of two forms of selectively deuterated 17-methyl-testosterone is described. 17-Methyl-d3-testosterone was prepared by the Grignard reaction of dehydroepiandrosterone with deuterium labeled methyl magnesium iodide followed by an Oppenauer oxidation. 17-Methyl-d3-testosterone-19,19,19-d3 was prepared by treating 3,3-ethylenedioxy-5,10-epoxy-5 alpha, 10 alpha-estran-17-one with deuterium labeled methyl magnesium bromide followed by hydrolysis and dehydration of the 5 alpha-hydroxyandrostane derivative.
- Research Organization:
- Tokyo College of Pharmacy, Japan
- OSTI ID:
- 5019653
- Journal Information:
- Steroids; (United States), Vol. 3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
TESTOSTERONE
CHEMICAL PREPARATION
CHEMISTRY
DEUTERIUM
LABELLED COMPOUNDS
ANDROGENS
ANDROSTANES
HORMONES
HYDROGEN ISOTOPES
HYDROXY COMPOUNDS
ISOTOPES
KETONES
LIGHT NUCLEI
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
STABLE ISOTOPES
STEROID HORMONES
STEROIDS
SYNTHESIS
550601* - Medicine- Unsealed Radionuclides in Diagnostics
TESTOSTERONE
CHEMICAL PREPARATION
CHEMISTRY
DEUTERIUM
LABELLED COMPOUNDS
ANDROGENS
ANDROSTANES
HORMONES
HYDROGEN ISOTOPES
HYDROXY COMPOUNDS
ISOTOPES
KETONES
LIGHT NUCLEI
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
STABLE ISOTOPES
STEROID HORMONES
STEROIDS
SYNTHESIS
550601* - Medicine- Unsealed Radionuclides in Diagnostics