Case-control study of lung cancer among workers at a uranium processing plant
The purpose of this case-control study was to investigate the relationship between exposure to radiation resulting from the inhalation of uranium dust and the dust of uranium-bearing compounds and death due to lung cancer. Cases and controls were chosen from a cohort of white male workers employed at one uranium processing plant during World War II. The 330 cases consisted of all lung cancer deaths occurring in the cohort between 1943 and 1973. Level of exposure to radiation and other potential workplace carcinogens was determined for each worker using process manuals, industrial hygiene reports, air monitoring data and individual work histories. Smoking status and information regarding medical variables was determined from employee medical records. Cumulative radiation lung dose among study population members ranged from 0 to 75 rads. Data were analyzed using Mantel-Haenszel stratified analysis and logistic regression. Relative risk was found to increase with increasing level of lung dose exposure even after controlling for age, smoking status and other workplace exposures, but only for those who were over the age of 44 when first exposed. A statistically significant excess in risk was found for men in this hire age group with a cumulative lung dose of 20 rads or more. The risk associated with the overall work environment was also investigated using a summary measure of total workplace exposure called chemical rank. A similar relationship existed between chemical rank and lung cancer to that found for cumulative lung dose and lung cancer.
- Research Organization:
- North Carolina Univ., Chapel Hill (USA)
- OSTI ID:
- 5019472
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LUNGS
NEOPLASMS
RADIATION DOSES
DISEASE INCIDENCE
ORE PROCESSING
RADIATION HAZARDS
URANIUM COMPOUNDS
AGE DEPENDENCE
AIR POLLUTION
DATA ANALYSIS
DATA COMPILATION
DOSE-RESPONSE RELATIONSHIPS
DUSTS
EPIDEMIOLOGY
INHALATION
MEDICAL RECORDS
OCCUPATIONAL EXPOSURE
RISK ASSESSMENT
TIME DEPENDENCE
TOBACCO SMOKES
ACTINIDE COMPOUNDS
AEROSOLS
BODY
COLLOIDS
DATA
DISEASES
DISPERSIONS
DOSES
HAZARDS
HEALTH HAZARDS
INFORMATION
INTAKE
NUMERICAL DATA
ORGANS
POLLUTION
PROCESSING
RESIDUES
RESPIRATORY SYSTEM
SMOKES
SOLS
560151* - Radiation Effects on Animals- Man