Permeability of the small intestine to (/sup 51/Cr)EDTA in children with acute gastroenteritis or eczema

Journal Article · Sat Jun 01 00:00:00 EDT 1985 · J. Pediatr. Gastroenterol. Nutr.; (United States)

DOI:https://doi.org/10.1097/00005176-198506000-00012· OSTI ID:5018768

Forget, P; Sodoyez-Goffaux, F; Zappitelli, A

Increased gut permeability to macromolecules is thought to be an important factor in the development of food hypersensitivity. The latter can develop in the course of acute gastroenteritis and could play a role in infantile eczema. The authors studied gut permeability in 10 normal adults, 11 control children, 7 children with acute gastroenteritis, and 8 patients with infantile eczema, making use of (/sup 51/Cr)EDTA as probe molecule. (/sup 51/Cr)EDTA was given orally (50-100 microCi); 24-h urinary excretion of (/sup 51/Cr)EDTA was measured and expressed as a percentage of the oral dose. Mean and standard error were 2.35 +/- 0.24, 2.51 +/- 0.21, 9.96 +/- 3.44, and 10.90 +/- 2.05 in normal adults, control children, and gastroenteritis and eczema patients, respectively. Differences between controls and either gastroenteritis (p less than 0.001) or eczema (p less than 0.001) patients are significant. The results support the hypothesis that increased gut permeability could play a role in food hypersensitivity.

• Research Organization: Univ. of Liege, Belgium
• OSTI ID: 5018768
• Journal Information: J. Pediatr. Gastroenterol. Nutr.; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
SMALL INTESTINE
PERMEABILITY
SENSITIVITY
CELL MEMBRANES
CHROMIUM 51
ECZEMA
EDTA
ENTERITIS
EXCRETION
FOOD
LABELLED COMPOUNDS
MOLECULES
PATIENTS
TRACER TECHNIQUES
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CHELATING AGENTS
CHROMIUM ISOTOPES
CLEARANCE
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOTOPE APPLICATIONS
ISOTOPES
MEMBRANES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
SKIN DISEASES
550901* - Pathology- Tracer Techniques