The nucleotide sequence of HLA-B{sup *}2704 reveals a new amino acid substitution in exon 4 which is also present in HLA-B{sup *}2706
Journal Article
·
· Immunogenetics
OSTI ID:501872
- John Radcliffe Hospital, Oxford (United Kingdom)
The HLA-B27 subtype HLA-B{sup *}2704 is virtually absent in Caucasians but common in Orientals, where it is associated with ankylosing spondylitis. The amino acid sequence of HLA-B{sup *}2704 has been established by peptide mapping and was shown to differ by two amino acids from HLA-B{sup *}2705, HLA-B{sup *}2704 is characterized by a serine for aspartic acid substitution at position 77 and glutamic acid for valine at position 152. To date, however, no nucleotide sequence confirming these changes at the DNA level has been published. 13 refs., 2 figs.
- OSTI ID:
- 501872
- Journal Information:
- Immunogenetics, Vol. 43, Issue 3; Other Information: PBD: 1996
- Country of Publication:
- United States
- Language:
- English
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