In vivo somatic mutation in the lymphocytes of Hodgkin's disease patients

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Environmental Management; (United States)

DOI:https://doi.org/10.1002/em.2850180103· OSTI ID:5017590

Caggana, M; Liber, H L; Mauch, P M; Coleman, C N; Kelsey, K T ^[1]

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1. Harvard Medical School, Boston, MA (United States)

While current medical therapies for Hodgkin's disease are usually quite effective, it has become increasingly clear that some of the therapies utilized carry an inherent risk for the induction of secondary malignancies. In order to examine the cellular and genetic responses to therapy for Hodgkin's disease among individuals, the authors have determined the mutant frequency of T-lymphocytes in 3 cohorts of patients and in controls using a T-cell cloning assay selecting for 6-thioguanine resistance. Overall, the results indicated that the individual response to Hodgkin's disease therapy was a heterogeneous one with a sub-population of persons having elevated mutant frequencies even many years after their last treatment. The larger frequency of elevated MFs in those patients who received intensive therapy (chemotherapy and radiotherapy) is consistent with their increased risk for second cancer induction.

• DOE Contract Number: FG02-89ER60745
• OSTI ID: 5017590
• Journal Information: Environmental Management; (United States), Vol. 18:1; ISSN 0364-152X
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOGENESIS
RISK ASSESSMENT
LYMPHOCYTES
MUTATION FREQUENCY
RADIOTHERAPY
SIDE EFFECTS
CHEMOTHERAPY
HODGKINS DISEASE
HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE
PATIENTS
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BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
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ELECTROMAGNETIC RADIATION
ENZYMES
GLYCOSYL TRANSFERASES
IMMUNE SYSTEM DISEASES
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOMAS
MATERIALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PATHOGENESIS
PENTOSYL TRANSFERASES
RADIATIONS
RADIOLOGY
SOMATIC CELLS
THERAPY
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